Gene description for Pgam2
Gene name phosphoglycerate mutase 2
Gene symbol Pgam2
Other names/aliases -
Species Mus musculus
 Database cross references - Pgam2
ExoCarta ExoCarta_56012
Entrez Gene 56012
UniProt O70250  
 Pgam2 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Pgam2
Molecular Function
    hydrolase activity GO:0016787 IEA
    bisphosphoglycerate 2-phosphatase activity GO:0004083 IEA
    protein binding GO:0005515 IPI
    cofactor binding GO:0048037 ISO
    bisphosphoglycerate mutase activity GO:0004082 IEA
    intramolecular transferase activity, phosphotransferases GO:0016868 IEA
    phosphoglycerate mutase activity GO:0004619 ISO
    2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity GO:0046538 ISO
    isomerase activity GO:0016853 IEA
    catalytic activity GO:0003824 IEA
Biological Process
    glycolytic process GO:0006096 ISO
    Notch signaling pathway GO:0007219 IDA
    response to inorganic substance GO:0010035 ISO
    gluconeogenesis GO:0006094 ISO
    striated muscle contraction GO:0006941 ISO
    response to mercury ion GO:0046689 ISO
    metabolic process GO:0008152 IEA
Subcellular Localization
    nucleus GO:0005634 ISO
    cytosol GO:0005829 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Pgam2 in exosomes
1
Experiment ID 210
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|FLOT1
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Pgam2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pgam2 is involved
PathwayEvidenceSource
Gluconeogenesis IEA Reactome
Glycolysis IEA Reactome





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