Gene description for PERP
Gene name PERP, TP53 apoptosis effector
Gene symbol PERP
Other names/aliases KCP1
KRTCAP1
PIGPC1
THW
dJ496H19.1
Species Homo sapiens
 Database cross references - PERP
ExoCarta ExoCarta_64065
Vesiclepedia VP_64065
Entrez Gene 64065
HGNC 17637
MIM 609301
UniProt Q96FX8  
 PERP identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 34887515    
 Gene ontology annotations for PERP
Biological Process
    amelogenesis GO:0097186 IEA
    positive regulation of proteolysis GO:0045862 IDA
    desmosome organization GO:0002934 IEA
    intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 IEA
    heterotypic cell-cell adhesion GO:0034113 IEA
    activation of cysteine-type endopeptidase activity GO:0097202 IDA
Subcellular Localization
    desmosome GO:0030057 IEA
    integral component of plasma membrane GO:0005887 IEA
    Golgi apparatus GO:0005794 IEA
    mitochondrion GO:0005739 IEA
 Experiment description of studies that identified PERP in exosomes
1
Experiment ID 1203
MISEV standards
EM
EV Biophysical techniques
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ.
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
 Protein-protein interactions for PERP
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PERP is involved
No pathways found





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