ExoCarta: Gene summary

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Gene description for PERP
Gene name	PERP, TP53 apoptosis effector
Gene symbol	PERP
Other names/aliases	KCP1 KRTCAP1 PIGPC1 THW dJ496H19.1
Species	Homo sapiens
Database cross references - PERP
ExoCarta	ExoCarta_64065
Vesiclepedia	VP_64065
Entrez Gene	64065
HGNC	17637
MIM	609301
UniProt	Q96FX8
PERP identified in sEVs derived from the following tissue/cell type
Colorectal cancer cells	34887515

Gene ontology annotations for PERP

Molecular Function
	protein binding	GO:0005515	IPI
Biological Process
	tissue homeostasis	GO:0001894	ISS
	desmosome organization	GO:0002934	IEA
	Notch signaling pathway	GO:0007219	IEA
	heterotypic cell-cell adhesion	GO:0034113	IEA
	positive regulation of proteolysis	GO:0045862	IDA
	mammary gland duct morphogenesis	GO:0060603	ISS
	positive regulation of T cell apoptotic process	GO:0070234	ISS
	intrinsic apoptotic signaling pathway by p53 class mediator	GO:0072332	IEA
	positive regulation of neutrophil chemotaxis	GO:0090023	IMP
	amelogenesis	GO:0097186	IEA
	activation of cysteine-type endopeptidase activity	GO:0097202	IDA
	cell-cell adhesion	GO:0098609	IBA
Subcellular Localization
	mitochondrion	GO:0005739	IEA
	Golgi apparatus	GO:0005794	IEA
	plasma membrane	GO:0005886	ISS
	plasma membrane	GO:0005886	TAS
	cell-cell junction	GO:0005911	IBA
	desmosome	GO:0030057	ISS

Experiment description of studies that identified PERP in sEVs

Experiment ID

1203

MISEV standards
✔ EM	Biophysical techniques
✔ SDCBP\|FLOT1\|CD9\|CD81\|CD63\|EPCAM\|GAPDH\|LAMP1\|TFRC\|CD151\|CD82\|LAMP2\|RAB35\|TSG101\|FLOT2\|RAB5B\|ICAM1\|RAB5A	Enriched markers
✘	Negative markers
✘	Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry

PubMed ID

34887515

Organism

Homo sapiens

Experiment description

Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets

Authors

"Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."

Journal name

Nat Cell Biol

Publication year

2021

Sample

Colorectal cancer cells

Sample name

DiFi

Isolation/purification methods

Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation

Flotation density

Molecules identified in the study

Protein
miRNA

Methods used in the study

Western blotting
Mass spectrometry
RNA sequencing

Protein-protein interactions for PERP

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

DCAF13

25879

Affinity Capture-Western

Homo sapiens

ABHD16A

7920

Two-hybrid

Homo sapiens

MAL

Two-hybrid

Homo sapiens

DDB1

1642

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

View the network

Pathways in which PERP is involved

Pathway	Evidence	Source
Developmental Biology	TAS	Reactome
Formation of the cornified envelope	TAS	Reactome
Gene expression (Transcription)	TAS	Reactome
Generic Transcription Pathway	TAS	Reactome
Keratinization	TAS	Reactome
RNA Polymerase II Transcription	TAS	Reactome
TP53 Regulates Transcription of Cell Death Genes	TAS	Reactome
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	TAS	Reactome
Transcriptional Regulation by TP53	TAS	Reactome

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