Gene description for SLC5A2
Gene name solute carrier family 5 (sodium/glucose cotransporter), member 2
Gene symbol SLC5A2
Other names/aliases SGLT2
Species Homo sapiens
 Database cross references - SLC5A2
ExoCarta ExoCarta_6524
Vesiclepedia VP_6524
Entrez Gene 6524
HGNC 11037
MIM 182381
UniProt P31639  
 SLC5A2 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for SLC5A2
Molecular Function
    low-affinity D-glucose:sodium symporter activity GO:0005362 TAS
    D-glucose:sodium symporter activity GO:0005412 EXP
    D-glucose:sodium symporter activity GO:0005412 IBA
    D-glucose:sodium symporter activity GO:0005412 IDA
    D-glucose:sodium symporter activity GO:0005412 TAS
    protein binding GO:0005515 IPI
    alpha-glucoside transmembrane transporter activity GO:0015151 IDA
    metal ion binding GO:0046872 IEA
    D-glucose transmembrane transporter activity GO:0055056 IDA
Biological Process
    alpha-glucoside transport GO:0000017 IDA
    carbohydrate metabolic process GO:0005975 TAS
    sodium ion transport GO:0006814 IBA
    hexose transmembrane transport GO:0008645 TAS
    renal D-glucose absorption GO:0035623 ISS
    D-glucose import across plasma membrane GO:0098708 IDA
    sodium ion import across plasma membrane GO:0098719 IDA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 TAS
    apical plasma membrane GO:0016324 ISS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified SLC5A2 in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
2
Experiment ID 196
MISEV standards
EM
Biophysical techniques
Alix|TSG101|HSP70|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 197
MISEV standards
EM
Biophysical techniques
Alix|TSG101|HSP70|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SLC5A2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TUBA3C 7278
Affinity Capture-MS Homo sapiens
2 GAPDHS 26330
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 ANLN 54443
Affinity Capture-MS Homo sapiens
4 AQP2 359
Two-hybrid Homo sapiens
View the network image/svg+xml



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