Gene description for BMP5
Gene name bone morphogenetic protein 5
Gene symbol BMP5
Other names/aliases -
Species Homo sapiens
 Database cross references - BMP5
ExoCarta ExoCarta_653
Vesiclepedia VP_653
Entrez Gene 653
HGNC 1072
MIM 112265
UniProt P22003  
 BMP5 identified in exosomes derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
 Gene ontology annotations for BMP5
Molecular Function
    cytokine activity GO:0005125 IBA
    BMP receptor binding GO:0070700 IDA
    transforming growth factor beta receptor binding GO:0005160 IBA
    growth factor activity GO:0008083 IEA
Biological Process
    regulation of MAPK cascade GO:0043408 IBA
    negative regulation of cortisol biosynthetic process GO:2000065 IDA
    skeletal system development GO:0001501 NAS
    SMAD protein signal transduction GO:0060395 IBA
    negative regulation of cell proliferation GO:0008285 IDA
    negative regulation of mononuclear cell migration GO:0071676 NAS
    pattern specification process GO:0007389 IEA
    growth GO:0040007 IEA
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 NAS
    positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 IDA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    ossification GO:0001503 IEA
    positive regulation of epithelial cell proliferation GO:0050679 IDA
    negative regulation of epithelial to mesenchymal transition GO:0010719 NAS
    negative regulation of aldosterone biosynthetic process GO:0032348 IDA
    positive regulation of dendrite development GO:1900006 IDA
    cartilage development GO:0051216 IEA
    BMP signaling pathway GO:0030509 IBA
    positive regulation of DNA-dependent DNA replication GO:2000105 IDA
    regulation of apoptotic process GO:0042981 IBA
    negative regulation of insulin-like growth factor receptor signaling pathway GO:0043569 IDA
    male genitalia development GO:0030539 IEA
    type B pancreatic cell development GO:0003323 IDA
    negative regulation of steroid biosynthetic process GO:0010894 IDA
Subcellular Localization
    cellular_component GO:0005575 ND
    membrane-bounded vesicle GO:0031988 ISS
    extracellular space GO:0005615 ISS
 Experiment description of studies that identified BMP5 in exosomes
1
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD.
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD.
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for BMP5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BMPR1A 657
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
2 FST 10468
Invivo Homo sapiens
3 NOG 9241
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which BMP5 is involved
No pathways found





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