Gene description for Spcs2
Gene name signal peptidase complex subunit 2 homolog (S. cerevisiae)
Gene symbol Spcs2
Other names/aliases 5730406I15Rik
AA408713
mKIAA0102
Species Mus musculus
 Database cross references - Spcs2
ExoCarta ExoCarta_66624
Entrez Gene 66624
UniProt Q9CYN2  
 Spcs2 identified in exosomes derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Spcs2
Molecular Function
    hydrolase activity GO:0016787 IEA
    molecular_function GO:0003674 ND
    peptidase activity GO:0008233 IEA
    cysteine-type peptidase activity GO:0008234 IEA
Biological Process
    biological_process GO:0008150 ND
    proteolysis GO:0006508 IEA
    signal peptide processing GO:0006465 IEA
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    cellular_component GO:0005575 ND
    membrane GO:0016020 IEA
    signal peptidase complex GO:0005787 IEA
    endoplasmic reticulum GO:0005783 IEA
    intracellular membrane-bounded organelle GO:0043231 IEA
 Experiment description of studies that identified Spcs2 in exosomes
1
Experiment ID 264
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th2 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Spcs2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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