Gene description for Spcs2
Gene name signal peptidase complex subunit 2 homolog (S. cerevisiae)
Gene symbol Spcs2
Other names/aliases 5730406I15Rik
AA408713
mKIAA0102
Species Mus musculus
 Database cross references - Spcs2
ExoCarta ExoCarta_66624
Vesiclepedia VP_66624
Entrez Gene 66624
UniProt Q9CYN2  
 Spcs2 identified in sEVs derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Spcs2
Biological Process
    signal peptide processing GO:0006465 IBA
    signal peptide processing GO:0006465 IEA
    signal peptide processing GO:0006465 ISO
    protein targeting to ER GO:0045047 IBA
Subcellular Localization
    signal peptidase complex GO:0005787 IBA
    signal peptidase complex GO:0005787 IEA
    signal peptidase complex GO:0005787 ISO
    endoplasmic reticulum membrane GO:0005789 ISO
 Experiment description of studies that identified Spcs2 in sEVs
1
Experiment ID 264
MISEV standards
✘ Biophysical techniques
✔
CD63|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-? via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors "Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino"
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th2 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Spcs2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC11A 23478
Affinity Capture-MS Homo sapiens
2 TTC37 9652
Affinity Capture-MS Homo sapiens
3 PGAP2  
Affinity Capture-MS Homo sapiens
4 Tmem173  
Proximity Label-MS Mus musculus
5 SPCS3 60559
Affinity Capture-MS Homo sapiens
6 MCM3AP  
Affinity Capture-MS Homo sapiens
7 KIF26B  
Affinity Capture-MS Homo sapiens
8 FAM111B 374393
Affinity Capture-MS Homo sapiens
9 Fancd2  
Affinity Capture-MS Mus musculus
10 BLMH 642
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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