Gene description for Atp2b1
Gene name ATPase, Ca++ transporting, plasma membrane 1
Gene symbol Atp2b1
Other names/aliases 2810442I22Rik
E130111D10Rik
Pmca1
Species Mus musculus
 Database cross references - Atp2b1
ExoCarta ExoCarta_67972
Vesiclepedia VP_67972
Entrez Gene 67972
UniProt G5E829  
 Atp2b1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Atp2b1
Molecular Function
    ATP binding GO:0005524 IEA
    PDZ domain binding GO:0030165 ISO
    hydrolase activity GO:0016787 IEA
    metal ion binding GO:0046872 IEA
    protein binding GO:0005515 IPI
    nucleotide binding GO:0000166 IEA
    calmodulin binding GO:0005516 IEA
    calcium-transporting ATPase activity GO:0005388 IEA
Biological Process
    calcium ion transport GO:0006816 TAS
    calcium ion transmembrane transport GO:0070588 IEA
    ion transport GO:0006811 IEA
    calcium ion export GO:1901660 ISO
    transport GO:0006810 IEA
Subcellular Localization
    cell junction GO:0030054 IEA
    membrane GO:0016020 ISO
    membrane raft GO:0045121 ISO
    apical plasma membrane GO:0016324 ISO
    apical part of cell GO:0045177 ISO
    nucleus GO:0005634 ISO
    plasma membrane GO:0005886 ISO
    integral component of plasma membrane GO:0005887 TAS
    synapse GO:0045202 IEA
    integral component of membrane GO:0016021 IEA
    cytoplasmic side of plasma membrane GO:0009898 ISO
    dendritic spine membrane GO:0032591 ISO
    dendrite membrane GO:0032590 ISO
    extracellular exosome GO:0070062 ISO
    basolateral plasma membrane GO:0016323 ISO
    neuronal cell body membrane GO:0032809 ISO
 Experiment description of studies that identified Atp2b1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Atp2b1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Atp2b1 is involved
PathwayEvidenceSource
Ion transport by P-type ATPases IEA Reactome
Reduction of cytosolic Ca++ levels IEA Reactome





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