Gene description for Trap1
Gene name TNF receptor-associated protein 1
Gene symbol Trap1
Other names/aliases 2410002K23Rik
HSP75
Species Mus musculus
 Database cross references - Trap1
ExoCarta ExoCarta_68015
Entrez Gene 68015
UniProt Q9CQN1  
 Trap1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Trap1
Molecular Function
    unfolded protein binding GO:0051082 IEA
    nucleotide binding GO:0000166 IEA
    ATP binding GO:0005524 IEA
    poly(A) RNA binding GO:0044822 ISO
    protein kinase binding GO:0019901 ISO
Biological Process
    negative regulation of cellular respiration GO:1901856 ISO
    negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 ISO
    translational attenuation GO:0009386 ISO
    protein folding GO:0006457 IEA
    response to stress GO:0006950 IEA
Subcellular Localization
    mitochondrial inner membrane GO:0005743 ISO
    mitochondrial matrix GO:0005759 ISO
    nucleoplasm GO:0005654 ISO
    mitochondrial intermembrane space GO:0005758 ISO
    mitochondrion GO:0005739 ISO
    membrane GO:0016020 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Trap1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Trap1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Trap1 is involved
No pathways found





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