Gene description for THBS4
Gene name thrombospondin 4
Gene symbol THBS4
Other names/aliases TSP-4
TSP4
Species Homo sapiens
 Database cross references - THBS4
ExoCarta ExoCarta_7060
Entrez Gene 7060
HGNC 11788
MIM 600715
UniProt P35443  
 THBS4 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for THBS4
Molecular Function
    calcium ion binding GO:0005509 IDA
    growth factor activity GO:0008083 IEA
    integrin binding GO:0005178 IDA
    heparin binding GO:0008201 IDA
    protein binding GO:0005515 IPI
Biological Process
    regulation of tissue remodeling GO:0034103 ISS
    response to unfolded protein GO:0006986 IEA
    behavioral response to pain GO:0048266 ISS
    positive regulation of cell division GO:0051781 IEA
    myoblast migration GO:0051451 IDA
    positive regulation of endothelial cell proliferation GO:0001938 IDA
    positive regulation of neutrophil chemotaxis GO:0090023 IDA
    negative regulation of angiogenesis GO:0016525 IEP
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA
    tissue remodeling GO:0048771 IEA
    response to endoplasmic reticulum stress GO:0034976 ISS
    endothelial cell-cell adhesion GO:0071603 IDA
Subcellular Localization
    sarcoplasmic reticulum GO:0016529 ISS
    extracellular space GO:0005615 IDA
    extracellular exosome GO:0070062 IDA
    extracellular region GO:0005576 TAS
    basement membrane GO:0005604 IDA
    extracellular matrix GO:0031012 ISS
    endoplasmic reticulum GO:0005783 ISS
 Experiment description of studies that identified THBS4 in exosomes
1
Experiment ID 275
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for THBS4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which THBS4 is involved
PathwayEvidenceSource
Signaling by PDGF TAS Reactome





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