Gene description for DAGLA
Gene name diacylglycerol lipase, alpha
Gene symbol DAGLA
Other names/aliases C11orf11
DAGL(ALPHA)
DAGLALPHA
NSDDR
Species Homo sapiens
 Database cross references - DAGLA
ExoCarta ExoCarta_747
Vesiclepedia VP_747
Entrez Gene 747
HGNC 1165
MIM 614015
UniProt Q9Y4D2  
 DAGLA identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for DAGLA
Molecular Function
    lipoprotein lipase activity GO:0004465 IBA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    monoacylglycerol lipase activity GO:0047372 TAS
Biological Process
    monoacylglycerol biosynthetic process GO:0006640 IEA
    neuroblast proliferation GO:0007405 IEA
    arachidonate metabolic process GO:0019369 IBA
    arachidonate metabolic process GO:0019369 IDA
    arachidonate metabolic process GO:0019369 TAS
    diacylglycerol catabolic process GO:0046340 IBA
    diacylglycerol catabolic process GO:0046340 IDA
    diacylglycerol catabolic process GO:0046340 IMP
    retrograde trans-synaptic signaling by endocannabinoid GO:0098921 IBA
    retrograde trans-synaptic signaling by endocannabinoid GO:0098921 IMP
    retrograde trans-synaptic signaling by endocannabinoid GO:0098921 ISS
    regulation of neuroinflammatory response GO:0150077 ISS
    cannabinoid biosynthetic process GO:1901696 IEA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    plasma membrane GO:0005886 TAS
    early endosome membrane GO:0031901 IDA
    dendrite membrane GO:0032590 IBA
    dendrite membrane GO:0032590 IDA
    dendritic spine membrane GO:0032591 ISS
    varicosity GO:0043196 IEA
    postsynaptic membrane GO:0045211 IBA
    postsynaptic density membrane GO:0098839 IDA
 Experiment description of studies that identified DAGLA in exosomes
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for DAGLA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UPK1B 7348
Two-hybrid Homo sapiens
2 MAL  
Two-hybrid Homo sapiens
3 NXF1 10482
Affinity Capture-RNA Homo sapiens
4 MCOLN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 DAGLB 221955
Negative Genetic Homo sapiens
6 VMA21  
Two-hybrid Homo sapiens
7 CMTM7  
Two-hybrid Homo sapiens
8 MOV10 4343
Affinity Capture-RNA Homo sapiens
9 MS4A13  
Two-hybrid Homo sapiens
10 TUSC5  
Two-hybrid Homo sapiens
11 TTYH1  
Affinity Capture-MS Homo sapiens
12 TMEM218  
Two-hybrid Homo sapiens
13 ZNRF4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 C3orf52  
Affinity Capture-MS Homo sapiens
15 LHFPL5  
Two-hybrid Homo sapiens
16 MALL  
Two-hybrid Homo sapiens
17 STOM 2040
Two-hybrid Homo sapiens
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