Gene description for WNT5B
Gene name wingless-type MMTV integration site family, member 5B
Gene symbol WNT5B
Other names/aliases -
Species Homo sapiens
 Database cross references - WNT5B
ExoCarta ExoCarta_81029
Entrez Gene 81029
HGNC 16265
MIM 606361
UniProt Q9H1J7  
 WNT5B identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for WNT5B
Molecular Function
    frizzled binding GO:0005109 IBA
    receptor binding GO:0005102 IPI
Biological Process
    wound healing GO:0042060 IEA
    positive regulation of cell migration GO:0030335 IDA
    neuron differentiation GO:0030182 ISS
    cell fate commitment GO:0045165 IBA
    negative regulation of canonical Wnt signaling pathway GO:0090090 IEA
    cellular response to retinoic acid GO:0071300 ISS
    Wnt signaling pathway GO:0016055 IMP
    lens fiber cell development GO:0070307 ISS
    positive regulation of fat cell differentiation GO:0045600 IEA
    chondrocyte differentiation GO:0002062 IEP
    fat cell differentiation GO:0045444 NAS
Subcellular Localization
    proteinaceous extracellular matrix GO:0005578 IEA
    extracellular exosome GO:0070062 IDA
    cell surface GO:0009986 IEA
    endoplasmic reticulum lumen GO:0005788 TAS
    plasma membrane GO:0005886 TAS
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 NAS
    Golgi lumen GO:0005796 TAS
 Experiment description of studies that identified WNT5B in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for WNT5B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APPBP2  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which WNT5B is involved
PathwayEvidenceSource
PCP/CE pathway TAS Reactome
WNT ligand biogenesis and trafficking TAS Reactome





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