Gene description for FCGR2C
Gene name Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
Gene symbol FCGR2C
Other names/aliases CD32
CD32C
CDW32
FCG2
FCRIIC
IGFR2
Species Homo sapiens
 Database cross references - FCGR2C
ExoCarta ExoCarta_9103
Vesiclepedia VP_9103
Entrez Gene 9103
HGNC 15626
MIM 612169
UniProt P31995  
 FCGR2C identified in sEVs derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for FCGR2C
Molecular Function
    transmembrane signaling receptor activity GO:0004888 NAS
    protein binding GO:0005515 IPI
    IgG receptor activity GO:0019770 IBA
    IgG binding GO:0019864 IBA
Biological Process
    antibody-dependent cellular cytotoxicity GO:0001788 IBA
    immune response GO:0006955 NAS
    cell surface receptor signaling pathway GO:0007166 IBA
    positive regulation of tumor necrosis factor production GO:0032760 IBA
    Fc-gamma receptor signaling pathway GO:0038094 IEA
    positive regulation of phagocytosis GO:0050766 IBA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    external side of plasma membrane GO:0009897 IBA
    membrane GO:0016020 NAS
 Experiment description of studies that identified FCGR2C in sEVs
1
Experiment ID 231
MISEV standards
Biophysical techniques
Alix|CD63|CD9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FCGR2C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ITGA4 3676
Affinity Capture-MS Homo sapiens
2 FCGR2A 2212
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FCGR2C is involved
No pathways found





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