Gene description for Acadl
Gene name acyl-Coenzyme A dehydrogenase, long-chain
Gene symbol Acadl
Other names/aliases AA960361
AU018452
C79855
LCAD
Species Mus musculus
 Database cross references - Acadl
ExoCarta ExoCarta_11363
Vesiclepedia VP_11363
Entrez Gene 11363
UniProt P51174  
 Acadl identified in sEVs derived from the following tissue/cell type
Melanoma cells 34957415    
Melanoma cells 34957415    
 Gene ontology annotations for Acadl
Molecular Function
    fatty-acyl-CoA binding GO:0000062 ISO
    long-chain fatty acyl-CoA dehydrogenase activity GO:0004466 IBA
    long-chain fatty acyl-CoA dehydrogenase activity GO:0004466 IDA
    long-chain fatty acyl-CoA dehydrogenase activity GO:0004466 ISO
    palmitoyl-CoA oxidase activity GO:0016401 IBA
    identical protein binding GO:0042802 ISO
    flavin adenine dinucleotide binding GO:0050660 IBA
    flavin adenine dinucleotide binding GO:0050660 IEA
    flavin adenine dinucleotide binding GO:0050660 ISO
Biological Process
    temperature homeostasis GO:0001659 IMP
    fatty acid catabolic process GO:0009062 IMP
    response to cold GO:0009409 IMP
    lipid catabolic process GO:0016042 IMP
    carnitine metabolic process, CoA-linked GO:0019254 IBA
    carnitine metabolic process, CoA-linked GO:0019254 IMP
    fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539 IBA
    fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539 IDA
    fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539 IMP
    fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539 ISO
    carnitine catabolic process GO:0042413 IMP
    long-chain fatty acid catabolic process GO:0042758 IBA
    long-chain fatty acid catabolic process GO:0042758 IEA
    long-chain fatty acid catabolic process GO:0042758 ISO
    negative regulation of fatty acid biosynthetic process GO:0045717 IMP
    negative regulation of fatty acid oxidation GO:0046322 IMP
    regulation of cholesterol metabolic process GO:0090181 IMP
    positive regulation of cold-induced thermogenesis GO:0120162 IMP
Subcellular Localization
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrial matrix GO:0005759 IEA
    mitochondrial matrix GO:0005759 ISO
    mitochondrial membrane GO:0031966 ISO
 Experiment description of studies that identified Acadl in sEVs
1
Experiment ID 1117
MISEV standards
Biophysical techniques
Cd81|Icam1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1R2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 1118
MISEV standards
Biophysical techniques
Cd81|Icam1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1R2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Acadl
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Got2 14719
Cross-Linking-MS (XL-MS) Mus musculus
2 Acadl 11363
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
3 Atp5a1 11946
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
4 Kctd13  
Affinity Capture-MS Mus musculus
5 Mecr  
Cross-Linking-MS (XL-MS) Mus musculus
6 HSD17B10 3028
Affinity Capture-MS Homo sapiens
7 Atp5b 11947
Cross-Linking-MS (XL-MS) Mus musculus
8 Ndufs3 68349
Cross-Linking-MS (XL-MS) Mus musculus
9 Acat1 110446
Cross-Linking-MS (XL-MS) Mus musculus
View the network image/svg+xml



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