Gene description for Hnrnpab
Gene name heterogeneous nuclear ribonucleoprotein A/B
Gene symbol Hnrnpab
Other names/aliases 3010025C11Rik
CBF-A
Cgbfa
Hnrpab
Species Mus musculus
 Database cross references - Hnrnpab
ExoCarta ExoCarta_15384
Vesiclepedia VP_15384
Entrez Gene 15384
UniProt Q99020  
 Hnrnpab identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
Mast cells 17486113    
Pancreatic cells 19351151    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Hnrnpab
Molecular Function
    DNA binding GO:0003677 IEA
    RNA binding GO:0003723 IBA
    RNA binding GO:0003723 IPI
    protein binding GO:0005515 IPI
    protein-containing complex binding GO:0044877 ISO
    sequence-specific double-stranded DNA binding GO:1990837 ISO
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IGI
    epithelial to mesenchymal transition GO:0001837 IDA
    regulation of gene expression GO:0010468 IBA
    mRNA modification GO:0016556 ISO
    positive regulation of DNA-templated transcription GO:0045893 IDA
    regulation of cellular localization GO:0060341 ISO
    chromosomal 5-methylcytosine DNA demethylation pathway GO:0141166 NAS
    regulation of intracellular mRNA localization GO:1904580 ISO
    negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:2000623 ISO
Subcellular Localization
    chromatin GO:0000785 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 IBA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 IDA
    dendrite GO:0030425 ISO
    mRNA editing complex GO:0045293 NAS
    neuronal ribonucleoprotein granule GO:0071598 ISO
    RNA polymerase II transcription regulator complex GO:0090575 IDA
    postsynapse GO:0098794 IDA
    glutamatergic synapse GO:0098978 IDA
    presynaptic cytosol GO:0099523 IDA
    ribonucleoprotein complex GO:1990904 ISO
    ribonucleoprotein complex GO:1990904 ISS
 Experiment description of studies that identified Hnrnpab in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
3
Experiment ID 188
MISEV standards
EM
Biophysical techniques
GAPDH|UCHL1|HSP90
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors "Lee HS, Jeong J, Lee KJ."
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Hnrnpab
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Rps3 27050
Co-fractionation Mus musculus
2 Ncbp1 433702
Co-fractionation Mus musculus
3 MKRN1 23608
Affinity Capture-MS Homo sapiens
4 Rpl13a 22121
Co-fractionation Mus musculus
5 Stau1  
Co-fractionation Mus musculus
6 Pou5f1  
Affinity Capture-MS Mus musculus
7 Ilf2 67781
Co-fractionation Mus musculus
8 Rps8 20116
Co-fractionation Mus musculus
9 Ybx1 22608
Co-fractionation Mus musculus
10 Fmr1  
Co-fractionation Mus musculus
11 Kctd13  
Affinity Capture-MS Mus musculus
12 Tfe3  
Affinity Capture-MS Mus musculus
13 Ncl 17975
Co-fractionation Mus musculus
14 Ywhae 22627
Affinity Capture-MS Mus musculus
15 Tmem173  
Proximity Label-MS Mus musculus
16 Rps9 76846
Co-fractionation Mus musculus
17 Unk  
Affinity Capture-RNA Mus musculus
18 Dmrt2  
Affinity Capture-MS Mus musculus
19 Sra1  
Co-fractionation Mus musculus
20 Tfcp2l1  
Affinity Capture-MS Mus musculus
21 Rps3a1 20091
Co-fractionation Mus musculus
22 Rplp0 11837
Co-fractionation Mus musculus
23 Atg16l1  
Affinity Capture-MS Mus musculus
24 Atg12  
Negative Genetic Mus musculus
25 Fancd2  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Hnrnpab is involved
No pathways found





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