Gene description for MPP7
Gene name membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
Gene symbol MPP7
Other names/aliases -
Species Homo sapiens
 Database cross references - MPP7
ExoCarta ExoCarta_143098
Vesiclepedia VP_143098
Entrez Gene 143098
HGNC 26542
MIM 610973
UniProt Q5T2T1  
 MPP7 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for MPP7
Molecular Function
    protein binding GO:0005515 IPI
    protein domain specific binding GO:0019904 IPI
    signaling adaptor activity GO:0035591 NAS
    signaling adaptor activity GO:0035591 TAS
    cadherin binding GO:0045296 HDA
    molecular adaptor activity GO:0060090 IDA
Biological Process
    establishment of cell polarity GO:0030010 TAS
    positive regulation of protein-containing complex assembly GO:0031334 IDA
    positive regulation of protein-containing complex assembly GO:0031334 TAS
    bicellular tight junction assembly GO:0070830 IDA
    protein localization to adherens junction GO:0071896 IBA
    protein localization to adherens junction GO:0071896 IMP
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    plasma membrane GO:0005886 IBA
    cell-cell junction GO:0005911 IBA
    adherens junction GO:0005912 IDA
    bicellular tight junction GO:0005923 IDA
    cell cortex GO:0005938 IEA
    lateral plasma membrane GO:0016328 IEA
    cell junction GO:0030054 IDA
    MPP7-DLG1-LIN7 complex GO:0097025 IDA
 Experiment description of studies that identified MPP7 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MPP7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BTK 695
Co-fractionation Homo sapiens
2 TRIM5 85363
Two-hybrid Homo sapiens
3 PHLPP1  
Proximity Label-MS Homo sapiens
4 ANKS4B  
Affinity Capture-MS Homo sapiens
5 GJD3  
Proximity Label-MS Homo sapiens
6 Wwtr1  
Affinity Capture-MS Mus musculus
7 Lin7c 22343
Affinity Capture-MS Mus musculus
8 EBAG9 9166
Proximity Label-MS Homo sapiens
9 OCLN 100506658
Proximity Label-MS Homo sapiens
10 KCNA4  
Affinity Capture-MS Homo sapiens
11 LIN7C 55327
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
12 KIF14 9928
Affinity Capture-MS Homo sapiens
13 MARCKS 4082
Proximity Label-MS Homo sapiens
14 OPALIN  
Affinity Capture-MS Homo sapiens
15 GJA1 2697
Proximity Label-MS Homo sapiens
16 SNX27 81609
Affinity Capture-MS Homo sapiens
17 CADM4 199731
Affinity Capture-MS Homo sapiens
18 EPB41L4A 64097
Proximity Label-MS Homo sapiens
19 LAMP1 3916
Proximity Label-MS Homo sapiens
20 RAB35 11021
Proximity Label-MS Homo sapiens
21 LCK 3932
Proximity Label-MS Homo sapiens
22 HSBP1 3281
Two-hybrid Homo sapiens
23 EFNB1 1947
Affinity Capture-MS Homo sapiens
24 ARF6 382
Proximity Label-MS Homo sapiens
25 EFNB3 1949
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 CXADR 1525
Proximity Label-MS Homo sapiens
27 DLGAP4 22839
Affinity Capture-MS Homo sapiens
28 C11orf52 91894
Proximity Label-MS Homo sapiens
29 WWC1  
Affinity Capture-MS Homo sapiens
30 SLC25A41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 LYN 4067
Proximity Label-MS Homo sapiens
32 KIF26B  
Affinity Capture-MS Homo sapiens
33 LIN7A 8825
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
34 MEIS2  
Affinity Capture-MS Homo sapiens
35 LAMTOR1 55004
Proximity Label-MS Homo sapiens
36 DNAJC5 80331
Proximity Label-MS Homo sapiens
37 HDGFRP2 84717
Affinity Capture-MS Homo sapiens
38 EPHA2 1969
Proximity Label-MS Homo sapiens
39 CDH1 999
Proximity Label-MS Homo sapiens
40 DIRAS3  
Proximity Label-MS Homo sapiens
41 ADAMTS1 9510
Affinity Capture-MS Homo sapiens
42 LIN7B  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
43 RAB11A 8766
Proximity Label-MS Homo sapiens
44 SSSCA1 10534
Affinity Capture-MS Homo sapiens
45 METTL21B  
Affinity Capture-MS Homo sapiens
46 RAB2A 5862
Proximity Label-MS Homo sapiens
47 PTPN4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 EFCAB11  
Affinity Capture-MS Homo sapiens
49 AMOT 154796
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 DLGAP2  
Affinity Capture-MS Homo sapiens
51 KRAS 3845
Proximity Label-MS Homo sapiens
52 Yap1  
Affinity Capture-MS Mus musculus
53 RHOB 388
Proximity Label-MS Homo sapiens
54 GPRC5B 51704
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 SLC31A1 1317
Affinity Capture-MS Homo sapiens
56 CAV1 857
Proximity Label-MS Homo sapiens
57 MYSM1  
Two-hybrid Homo sapiens
58 FLOT1 10211
Proximity Label-MS Homo sapiens
59 STX6 10228
Proximity Label-MS Homo sapiens
60 BTNL9  
Affinity Capture-MS Homo sapiens
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