Gene description for ELP2
Gene name elongator acetyltransferase complex subunit 2
Gene symbol ELP2
Other names/aliases SHINC-2
STATIP1
StIP
Species Homo sapiens
 Database cross references - ELP2
ExoCarta ExoCarta_55250
Vesiclepedia VP_55250
Entrez Gene 55250
HGNC 18248
MIM 616054
UniProt Q6IA86  
 ELP2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for ELP2
Molecular Function
    RNA polymerase II complex binding GO:0000993 IDA
    protein kinase binding GO:0019901 IEA
Biological Process
    tRNA wobble uridine modification GO:0002098 NAS
    regulation of transcription by RNA polymerase II GO:0006357 TAS
    transcription elongation by RNA polymerase II GO:0006368 TAS
    regulation of translation GO:0006417 NAS
    regulation of receptor signaling pathway via JAK-STAT GO:0046425 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 NAS
    cytosol GO:0005829 IDA
    transcription elongation factor complex GO:0008023 IDA
    elongator holoenzyme complex GO:0033588 IBA
    elongator holoenzyme complex GO:0033588 IDA
    elongator holoenzyme complex GO:0033588 IPI
 Experiment description of studies that identified ELP2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ELP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SNRPB2 6629
Co-fractionation Homo sapiens
2 UBE2H 7328
Affinity Capture-MS Homo sapiens
3 FTL 2512
Affinity Capture-MS Homo sapiens
4 PAAF1 80227
Co-fractionation Homo sapiens
5 MPG 4350
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 IKBKAP 8518
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
7 KPTN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 HUWE1 10075
Affinity Capture-MS Homo sapiens
9 ZMYM1 79830
Affinity Capture-MS Homo sapiens
10 STAT5B 6777
Reconstituted Complex Homo sapiens
11 ELP6 54859
Affinity Capture-MS Homo sapiens
12 TP53 7157
Affinity Capture-MS Homo sapiens
13 DDX58 23586
Affinity Capture-RNA Homo sapiens
14 CIAO1 9391
Affinity Capture-MS Homo sapiens
15 C9orf78 51759
Affinity Capture-MS Homo sapiens
16 NUBP2 10101
Affinity Capture-MS Homo sapiens
17 WRNIP1 56897
Co-fractionation Homo sapiens
18 RIT1 6016
Negative Genetic Homo sapiens
19 USP34 9736
Co-fractionation Homo sapiens
20 DNAJA2 10294
Affinity Capture-MS Homo sapiens
21 RPA2 6118
Co-fractionation Homo sapiens
22 CAMK2A 815
Affinity Capture-MS Homo sapiens
23 KCMF1 56888
Affinity Capture-MS Homo sapiens
24 DLD 1738
Affinity Capture-MS Homo sapiens
25 C2orf27B  
Affinity Capture-MS Homo sapiens
26 ELP3 55140
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
27 ASAP3 55616
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 PRPSAP2 5636
Co-fractionation Homo sapiens
29 CTDP1 9150
Reconstituted Complex Homo sapiens
30 POLR2D  
Co-fractionation Homo sapiens
31 MTO1  
Affinity Capture-MS Homo sapiens
32 SHMT2 6472
Affinity Capture-RNA Homo sapiens
33 FAM219B 57184
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 FAM96B 51647
Affinity Capture-MS Homo sapiens
35 NXF1 10482
Affinity Capture-RNA Homo sapiens
36 UBR4 23352
Affinity Capture-MS Homo sapiens
37 FKBP5 2289
Affinity Capture-MS Homo sapiens
38 PARK2  
Affinity Capture-MS Homo sapiens
39 PTPN21 11099
Affinity Capture-MS Homo sapiens
40 MOV10 4343
Affinity Capture-RNA Homo sapiens
41 RPA3 6119
Proximity Label-MS Homo sapiens
42 JAK1 3716
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
43 DYRK1A 1859
Affinity Capture-MS Homo sapiens
44 C16orf72 29035
Affinity Capture-MS Homo sapiens
45 NTRK1 4914
Affinity Capture-MS Homo sapiens
46 RAB24 53917
Affinity Capture-MS Homo sapiens
47 PIGQ  
Affinity Capture-MS Homo sapiens
48 CD2AP 23607
Co-fractionation Homo sapiens
49 KIF5B 3799
Co-fractionation Homo sapiens
50 TAF9 6880
Co-fractionation Homo sapiens
51 DUSP9  
Affinity Capture-MS Homo sapiens
52 MATR3 9782
Co-fractionation Homo sapiens
53 CAMK2D 817
Affinity Capture-MS Homo sapiens
54 STAT3 6774
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
55 C9orf72  
Affinity Capture-MS Homo sapiens
56 KRAS 3845
Negative Genetic Homo sapiens
57 STYX  
Affinity Capture-MS Homo sapiens
58 HSPA12A 259217
Proximity Label-MS Homo sapiens
59 STAT1 6772
Reconstituted Complex Homo sapiens
60 JAK2 3717
Affinity Capture-Western Homo sapiens
61 KIAA1033 23325
Co-fractionation Homo sapiens
62 PADI4  
Affinity Capture-MS Homo sapiens
63 NRBP1 29959
Co-fractionation Homo sapiens
64 EP300 2033
Affinity Capture-MS Homo sapiens
65 PLEKHN1  
Affinity Capture-MS Homo sapiens
66 ELP4  
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
67 TYK2 7297
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which ELP2 is involved
PathwayEvidenceSource
Chromatin modifying enzymes IEA Reactome
Chromatin organization IEA Reactome
HATs acetylate histones IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here