Gene description for NAALAD2
Gene name N-acetylated alpha-linked acidic dipeptidase 2
Gene symbol NAALAD2
Other names/aliases GCPIII
GPCIII
NAADALASE2
NAALADASE2
Species Homo sapiens
 Database cross references - NAALAD2
ExoCarta ExoCarta_10003
Entrez Gene 10003
HGNC 14526
MIM 611636
UniProt Q9Y3Q0  
 NAALAD2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for NAALAD2
Molecular Function
    N-formylglutamate deformylase activity GO:0050129 IEA
    metallopeptidase activity GO:0008237 IEA
    serine-type peptidase activity GO:0008236 NAS
    metal ion binding GO:0046872 IEA
    dipeptidase activity GO:0016805 NAS
    dipeptidyl-peptidase activity GO:0008239 NAS
    carboxypeptidase activity GO:0004180 NAS
Biological Process
    neurotransmitter catabolic process GO:0042135 IEA
    proteolysis GO:0006508 NAS
Subcellular Localization
    integral component of membrane GO:0016021 NAS
 Experiment description of studies that identified NAALAD2 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for NAALAD2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which NAALAD2 is involved
No pathways found





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