Gene description for MXD4
Gene name MAX dimerization protein 4
Gene symbol MXD4
Other names/aliases MAD4
MST149
MSTP149
bHLHc12
Species Homo sapiens
 Database cross references - MXD4
ExoCarta ExoCarta_10608
Entrez Gene 10608
HGNC 13906
UniProt Q14582  
 MXD4 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for MXD4
Molecular Function
    protein binding GO:0005515 IPI
    protein dimerization activity GO:0046983 IEA
    transcription corepressor activity GO:0003714 TAS
    DNA binding GO:0003677 IEA
Biological Process
    transcription, DNA-templated GO:0006351 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 TAS
    negative regulation of cell proliferation GO:0008285 TAS
Subcellular Localization
    nucleus GO:0005634 IEA
 Experiment description of studies that identified MXD4 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for MXD4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAX  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
2 TCP10L  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
3 MLX  
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which MXD4 is involved
No pathways found





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