Gene description for STARD10
Gene name StAR-related lipid transfer (START) domain containing 10
Gene symbol STARD10
Other names/aliases CGI-52
NY-CO-28
PCTP2
SDCCAG28
Species Homo sapiens
 Database cross references - STARD10
ExoCarta ExoCarta_10809
Vesiclepedia VP_10809
Entrez Gene 10809
HGNC 10666
UniProt Q9Y365  
 STARD10 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 34887515    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for STARD10
Molecular Function
    protein binding GO:0005515 IPI
    lipid binding GO:0008289 IEA
Biological Process
    lipid transport GO:0006869 IEA
Subcellular Localization
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    microvillus GO:0005902 IBA
    membrane GO:0016020 IBA
    motile cilium GO:0031514 IEA
    intercellular canaliculus GO:0046581 IBA
 Experiment description of studies that identified STARD10 in exosomes
1
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
2
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for STARD10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Reconstituted Complex Homo sapiens
2 STRN4 29888
Cross-Linking-MS (XL-MS) Homo sapiens
3 NELFE 7936
Affinity Capture-MS Homo sapiens
4 STRN3 29966
Cross-Linking-MS (XL-MS) Homo sapiens
5 STRN 6801
Cross-Linking-MS (XL-MS) Homo sapiens
6 BAG1 573
Affinity Capture-MS Homo sapiens
7 GRB2 2885
Affinity Capture-MS Homo sapiens
8 PRMT6  
Two-hybrid Homo sapiens
9 GOT1 2805
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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