Gene description for MMP24
Gene name matrix metallopeptidase 24 (membrane-inserted)
Gene symbol MMP24
Other names/aliases MMP-24
MMP25
MT-MMP 5
MT-MMP5
MT5-MMP
MT5MMP
MTMMP5
Species Homo sapiens
 Database cross references - MMP24
ExoCarta ExoCarta_10893
Vesiclepedia VP_10893
Entrez Gene 10893
HGNC 7172
MIM 604871
UniProt Q9Y5R2  
 MMP24 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for MMP24
Molecular Function
    metalloendopeptidase activity GO:0004222 IBA
    metalloendopeptidase activity GO:0004222 ISS
    enzyme activator activity GO:0008047 TAS
    zinc ion binding GO:0008270 IEA
    cadherin binding GO:0045296 IEA
Biological Process
    proteolysis GO:0006508 ISS
    glial cell differentiation GO:0010001 ISS
    extracellular matrix organization GO:0030198 IBA
    collagen catabolic process GO:0030574 IBA
    cell-cell adhesion mediated by cadherin GO:0044331 ISS
    detection of temperature stimulus involved in sensory perception of pain GO:0050965 ISS
    neuronal stem cell population maintenance GO:0097150 ISS
    cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 ISS
Subcellular Localization
    extracellular space GO:0005615 IBA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISS
    extracellular matrix GO:0031012 IEA
    trans-Golgi network membrane GO:0032588 ISS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified MMP24 in exosomes
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for MMP24
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UHRF1BP1 54887
Affinity Capture-MS Homo sapiens
2 UBE2O 63893
Affinity Capture-MS Homo sapiens
3 BUD31 8896
Two-hybrid Homo sapiens
View the network image/svg+xml



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