Gene description for MMP24
Gene name matrix metallopeptidase 24 (membrane-inserted)
Gene symbol MMP24
Other names/aliases MMP-24
MMP25
MT-MMP 5
MT-MMP5
MT5-MMP
MT5MMP
MTMMP5
Species Homo sapiens
 Database cross references - MMP24
ExoCarta ExoCarta_10893
Entrez Gene 10893
HGNC 7172
MIM 604871
UniProt Q9Y5R2  
 MMP24 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for MMP24
Molecular Function
    calcium ion binding GO:0005509 IEA
    metalloendopeptidase activity GO:0004222 ISS
    enzyme activator activity GO:0008047 TAS
    zinc ion binding GO:0008270 IEA
    cadherin binding GO:0045296 IEA
Biological Process
    neuronal stem cell maintenance GO:0097150 ISS
    proteolysis GO:0006508 ISS
    detection of temperature stimulus involved in sensory perception of pain GO:0050965 ISS
    glial cell differentiation GO:0010001 ISS
    positive regulation of catalytic activity GO:0043085 TAS
    cell-cell adhesion GO:0098609 ISS
    cell-cell adhesion mediated by cadherin GO:0044331 ISS
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    trans-Golgi network membrane GO:0032588 ISS
    integral component of plasma membrane GO:0005887 ISS
    proteinaceous extracellular matrix GO:0005578 IEA
 Experiment description of studies that identified MMP24 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for MMP24
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MMP24 is involved
PathwayEvidenceSource
Activation of Matrix Metalloproteinases TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here