Gene description for TMEM123
Gene name transmembrane protein 123
Gene symbol TMEM123
Other names/aliases KCT3
PORIMIN
PORMIN
Species Homo sapiens
 Database cross references - TMEM123
ExoCarta ExoCarta_114908
Entrez Gene 114908
HGNC 30138
MIM 606356
UniProt Q8N131  
 TMEM123 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for TMEM123
Molecular Function
    protein binding GO:0005515 IPI
    receptor activity GO:0004872 NAS
Biological Process
    oncosis GO:0070267 IDA
Subcellular Localization
    integral component of membrane GO:0016021 NAS
    external side of plasma membrane GO:0009897 IDA
 Experiment description of studies that identified TMEM123 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for TMEM123
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAGEA11  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TMEM123 is involved
No pathways found





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