Gene description for Aldh2
Gene name aldehyde dehydrogenase 2, mitochondrial
Gene symbol Aldh2
Other names/aliases AHD-M1
ALDH-E2
ALDHI
Ahd-5
Ahd5
Species Mus musculus
 Database cross references - Aldh2
ExoCarta ExoCarta_11669
Vesiclepedia VP_11669
Entrez Gene 11669
UniProt P47738  
 Aldh2 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Aldh2
Molecular Function
    oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016620 IEA
    NADH binding GO:0070404 ISO
    aldehyde dehydrogenase (NAD) activity GO:0004029 ISO
    identical protein binding GO:0042802 ISO
    protein binding GO:0005515 IPI
    oxidoreductase activity GO:0016491 IEA
Biological Process
    negative regulation of apoptotic process GO:0043066 ISO
    oxidation-reduction process GO:0055114 IBA
    metabolic process GO:0008152 IEA
Subcellular Localization
    mitochondrion GO:0005739 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Aldh2 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Aldh2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Aldh2 is involved
PathwayEvidenceSource
Ethanol oxidation IEA Reactome
Metabolism of serotonin IEA Reactome





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