Gene description for Hyou1
Gene name hypoxia up-regulated 1
Gene symbol Hyou1
Other names/aliases AI415631
Species Mus musculus
 Database cross references - Hyou1
ExoCarta ExoCarta_12282
Entrez Gene 12282
UniProt Q9JKR6  
 Hyou1 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Hyou1
Molecular Function
    nucleotide binding GO:0000166 IEA
    ATP binding GO:0005524 IEA
Biological Process
    response to hypoxia GO:0001666 ISO
    cellular response to hypoxia GO:0071456 ISO
    response to ischemia GO:0002931 IDA
    negative regulation of apoptotic process GO:0043066 IMP
    negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway GO:1903382 IMP
    negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway GO:1903298 ISO
Subcellular Localization
    focal adhesion GO:0005925 ISO
    membrane GO:0016020 ISO
    extracellular exosome GO:0070062 ISO
    endoplasmic reticulum GO:0005783 IEA
    endoplasmic reticulum chaperone complex GO:0034663 IDA
    smooth endoplasmic reticulum GO:0005790 ISO
 Experiment description of studies that identified Hyou1 in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Hyou1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Hyou1 is involved
Scavenging by Class F Receptors IEA Reactome

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