Gene description for Cat
Gene name catalase
Gene symbol Cat
Other names/aliases 2210418N07
Cas-1
Cas1
Cs-1
Species Mus musculus
 Database cross references - Cat
ExoCarta ExoCarta_12359
Vesiclepedia VP_12359
Entrez Gene 12359
UniProt P24270  
 Cat identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Cat
Molecular Function
    oxidoreductase activity GO:0016491 IEA
    metal ion binding GO:0046872 IEA
    antioxidant activity GO:0016209 ISO
    oxidoreductase activity, acting on peroxide as acceptor GO:0016684 IDA
    catalase activity GO:0004096 ISO
    aminoacylase activity GO:0004046 IMP
    protein homodimerization activity GO:0042803 ISO
    peroxidase activity GO:0004601 IEA
    receptor binding GO:0005102 ISO
    enzyme binding GO:0019899 ISO
    NADP binding GO:0050661 ISO
    heme binding GO:0020037 ISO
Biological Process
    protein tetramerization GO:0051262 ISO
    negative regulation of apoptotic process GO:0043066 ISO
    response to oxidative stress GO:0006979 ISO
    response to hypoxia GO:0001666 ISO
    osteoblast differentiation GO:0001649 ISO
    UV protection GO:0009650 ISO
    hemoglobin metabolic process GO:0020027 IMP
    positive regulation of cell division GO:0051781 IEA
    kidney development GO:0001822 ISO
    aerobic respiration GO:0009060 IMP
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IDA
    ureteric bud development GO:0001657 ISO
    negative regulation of NF-kappaB transcription factor activity GO:0032088 IDA
    response to reactive oxygen species GO:0000302 ISO
    hydrogen peroxide catabolic process GO:0042744 ISO
    triglyceride metabolic process GO:0006641 IMP
    protein homotetramerization GO:0051289 ISO
    oxidation-reduction process GO:0055114 ISO
    cholesterol metabolic process GO:0008203 IMP
    positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 IDA
Subcellular Localization
    membrane GO:0016020 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    mitochondrion GO:0005739 IDA
    lysosome GO:0005764 ISO
    peroxisomal membrane GO:0005778 IDA
    Golgi apparatus GO:0005794 ISO
    mitochondrial intermembrane space GO:0005758 ISO
    plasma membrane GO:0005886 ISO
    endoplasmic reticulum GO:0005783 ISO
    peroxisome GO:0005777 ISO
    cytosol GO:0005829 ISO
    extracellular exosome GO:0070062 ISO
    extracellular space GO:0005615 ISO
    focal adhesion GO:0005925 ISO
 Experiment description of studies that identified Cat in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Cat
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cat is involved
PathwayEvidenceSource
Detoxification of Reactive Oxygen Species IEA Reactome
Purine catabolism IEA Reactome





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