Gene description for Dbt
Gene name dihydrolipoamide branched chain transacylase E2
Gene symbol Dbt
Other names/aliases D3Wsu60e
Species Mus musculus
 Database cross references - Dbt
ExoCarta ExoCarta_13171
Entrez Gene 13171
UniProt P53395  
 Dbt identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Dbt
Molecular Function
    transferase activity, transferring acyl groups GO:0016746 IEA
    ubiquitin protein ligase binding GO:0031625 ISO
    dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity GO:0043754 IEA
    transferase activity GO:0016740 IEA
Biological Process
    metabolic process GO:0008152 IEA
Subcellular Localization
    mitochondrion GO:0005739 ISO
    mitochondrial nucleoid GO:0042645 ISO
 Experiment description of studies that identified Dbt in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Dbt
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Dbt is involved
PathwayEvidenceSource
Branched-chain amino acid catabolism IEA Reactome





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