Gene description for Fbln1
Gene name fibulin 1
Gene symbol Fbln1
Other names/aliases -
Species Mus musculus
 Database cross references - Fbln1
ExoCarta ExoCarta_14114
Entrez Gene 14114
UniProt Q08879  
 Fbln1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Fbln1
Molecular Function
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    peptidase activator activity GO:0016504 IDA
Biological Process
    positive regulation of peptidase activity GO:0010952 IDA
    extracellular matrix organization GO:0030198 IDA
Subcellular Localization
    extracellular matrix GO:0031012 ISO
    extracellular space GO:0005615 ISO
    extracellular exosome GO:0070062 ISO
    proteinaceous extracellular matrix GO:0005578 IEA
    basement membrane GO:0005604 IDA
    extracellular region GO:0005576 IEA
 Experiment description of studies that identified Fbln1 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Fbln1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Fbln1 is involved
PathwayEvidenceSource
Molecules associated with elastic fibres IEA Reactome





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