Gene description for Fga
Gene name fibrinogen alpha chain
Gene symbol Fga
Other names/aliases ENSMUSG00000059807
Fib
Species Mus musculus
 Database cross references - Fga
ExoCarta ExoCarta_14161
Vesiclepedia VP_14161
Entrez Gene 14161
UniProt E9PV24  
 Fga identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Fga
Molecular Function
    protein binding, bridging GO:0030674 IEA
    cell adhesion molecule binding GO:0050839 ISO
    receptor binding GO:0005102 ISO
    structural molecule activity GO:0005198 ISO
Biological Process
    cell-matrix adhesion GO:0007160 ISO
    blood coagulation, common pathway GO:0072377 ISO
    hemostasis GO:0007599 IEA
    positive regulation of peptide hormone secretion GO:0090277 ISO
    positive regulation of heterotypic cell-cell adhesion GO:0034116 ISO
    signal transduction GO:0007165 IEA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO
    immune system process GO:0002376 IEA
    negative regulation of endothelial cell apoptotic process GO:2000352 ISO
    response to calcium ion GO:0051592 ISO
    positive regulation of exocytosis GO:0045921 ISO
    positive regulation of protein secretion GO:0050714 ISO
    innate immune response GO:0045087 IEA
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 ISO
    platelet aggregation GO:0070527 ISO
    protein polymerization GO:0051258 ISO
    platelet activation GO:0030168 IEA
    blood coagulation GO:0007596 IMP
    positive regulation of vasoconstriction GO:0045907 ISO
    induction of bacterial agglutination GO:0043152 ISO
    cellular protein complex assembly GO:0043623 ISO
Subcellular Localization
    cell cortex GO:0005938 IDA
    extracellular exosome GO:0070062 ISO
    fibrinogen complex GO:0005577 ISO
    external side of plasma membrane GO:0009897 ISO
    platelet alpha granule GO:0031091 ISO
    cytoplasm GO:0005737 ISO
    rough endoplasmic reticulum GO:0005791 ISO
    extracellular vesicle GO:1903561 ISO
    cell surface GO:0009986 ISO
    extracellular region GO:0005576 IEA
    blood microparticle GO:0072562 ISO
    extracellular space GO:0005615 ISO
 Experiment description of studies that identified Fga in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Fga
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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