Gene description for Smc2
Gene name structural maintenance of chromosomes 2
Gene symbol Smc2
Other names/aliases 5730502P04Rik
AI255214
AW545314
CAP-E
CAPE
Fin16
SMC-2
Smc2l1
Species Mus musculus
 Database cross references - Smc2
ExoCarta ExoCarta_14211
Entrez Gene 14211
UniProt Q8CG48  
 Smc2 identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Smc2
Molecular Function
    ATP binding GO:0005524 IEA
    protein heterodimerization activity GO:0046982 ISO
    protein binding GO:0005515 IPI
    nucleotide binding GO:0000166 IEA
Biological Process
    mitotic chromosome condensation GO:0007076 ISO
    meiotic chromosome segregation GO:0045132 IMP
    chromosome organization GO:0051276 IEA
    chromosome condensation GO:0030261 IEA
    cell division GO:0051301 IEA
    meiotic chromosome condensation GO:0010032 IMP
    mitotic nuclear division GO:0007067 IEA
    kinetochore organization GO:0051383 IMP
    cell cycle GO:0007049 IEA
Subcellular Localization
    nuclear chromosome GO:0000228 ISO
    cytoplasm GO:0005737 ISO
    extracellular exosome GO:0070062 ISO
    condensin complex GO:0000796 ISO
    nucleus GO:0005634 ISO
    condensed chromosome GO:0000793 ISO
    chromosome GO:0005694 IEA
 Experiment description of studies that identified Smc2 in exosomes
1
Experiment ID 188
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH|UCHL1|HSP90
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Smc2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Smc2 is involved
PathwayEvidenceSource
Condensation of Prometaphase Chromosomes IEA Reactome
Condensation of Prophase Chromosomes IEA Reactome





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