Gene description for Smc4
Gene name structural maintenance of chromosomes 4
Gene symbol Smc4
Other names/aliases 2500002A22Rik
C79747
SMC-4
Smc4l1
Species Mus musculus
 Database cross references - Smc4
ExoCarta ExoCarta_70099
Entrez Gene 70099
UniProt Q8CG47  
 Smc4 identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Smc4
Molecular Function
    ATP binding GO:0005524 IEA
    protein binding GO:0005515 IPI
    nucleotide binding GO:0000166 IEA
    protein heterodimerization activity GO:0046982 ISO
Biological Process
    cell cycle GO:0007049 IEA
    meiotic chromosome condensation GO:0010032 IMP
    meiotic chromosome segregation GO:0045132 IMP
    mitotic chromosome condensation GO:0007076 ISO
    chromosome organization GO:0051276 IEA
    cell division GO:0051301 IEA
    kinetochore organization GO:0051383 IMP
    mitotic nuclear division GO:0007067 IEA
    chromosome condensation GO:0030261 IEA
Subcellular Localization
    chromosome GO:0005694 IEA
    cytoplasm GO:0005737 ISO
    condensin complex GO:0000796 ISO
    nucleus GO:0005634 IEA
    nucleoplasm GO:0005654 ISO
 Experiment description of studies that identified Smc4 in exosomes
1
Experiment ID 188
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH|UCHL1|HSP90
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Smc4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Smc4 is involved
PathwayEvidenceSource
Condensation of Prometaphase Chromosomes IEA Reactome
Condensation of Prophase Chromosomes IEA Reactome





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