Gene description for Il1rap
Gene name interleukin 1 receptor accessory protein
Gene symbol Il1rap
Other names/aliases 6430709H04Rik
AI255955
AV239853
IL-1RAcP
Species Mus musculus
 Database cross references - Il1rap
ExoCarta ExoCarta_16180
Vesiclepedia VP_16180
Entrez Gene 16180
UniProt Q61730  
 Il1rap identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Il1rap
Molecular Function
    signal transducer activity GO:0004871 IDA
    interleukin-1 receptor binding GO:0005149 ISO
    interleukin-1 receptor activity GO:0004908 IDA
    protein binding GO:0005515 IPI
Biological Process
    signal transduction GO:0007165 IEA
    cytokine-mediated signaling pathway GO:0019221 IDA
    innate immune response GO:0045087 IEA
    interleukin-2 biosynthetic process GO:0042094 IDA
    immune system process GO:0002376 IEA
    inflammatory response GO:0006954 IEA
Subcellular Localization
    extracellular region GO:0005576 IEA
    membrane GO:0016020 ISO
    integral component of membrane GO:0016021 IEA
    cytoplasm GO:0005737 ISO
    protein complex GO:0043234 ISO
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified Il1rap in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Il1rap
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Il1rap is involved
PathwayEvidenceSource
Interleukin-1 signaling IEA Reactome





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