Gene description for Hyou1
Gene name hypoxia up-regulated 1
Gene symbol Hyou1
Other names/aliases Cab140
Orp150
Species Rattus norvegicus
 Database cross references - Hyou1
ExoCarta ExoCarta_192235
Entrez Gene 192235
UniProt Q63617  
 Hyou1 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Hyou1
Molecular Function
    ATP binding GO:0005524 IEA
Biological Process
    negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway GO:1903298 ISO
    negative regulation of apoptotic process GO:0043066 ISO
    response to hypoxia GO:0001666 IDA
    response to endoplasmic reticulum stress GO:0034976 ISO
    response to ischemia GO:0002931 ISO
    cellular response to hypoxia GO:0071456 ISO
    negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway GO:1903382 ISO
Subcellular Localization
    endoplasmic reticulum lumen GO:0005788 IEA
    membrane GO:0016020 ISO
    focal adhesion GO:0005925 ISO
    extracellular exosome GO:0070062 ISO
    endoplasmic reticulum chaperone complex GO:0034663 ISO
    smooth endoplasmic reticulum GO:0005790 IDA
 Experiment description of studies that identified Hyou1 in exosomes
1
Experiment ID 225
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Hyou1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Hyou1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here