Gene description for Hspa5
Gene name	heat shock protein 5
Gene symbol	Hspa5
Other names/aliases	BIP GRP78
Species	Rattus norvegicus
Database cross references - Hspa5
ExoCarta	ExoCarta_25617
Vesiclepedia	VP_25617
Entrez Gene	25617
UniProt	P06761
Hspa5 identified in exosomes derived from the following tissue/cell type
Adipocytes	25998041
Hepatocytes	19367702
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Hspa5

Molecular Function     DNA clamp loader activity GO:0003689 IEA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     ATP binding GO:0005524 ISO     ATP hydrolysis activity GO:0016887 IBA     ATP hydrolysis activity GO:0016887 IEA     ATP hydrolysis activity GO:0016887 ISO     ATP hydrolysis activity GO:0016887 ISS     enzyme binding GO:0019899 ISO     protein domain specific binding GO:0019904 IEA     protein domain specific binding GO:0019904 ISO     protein serine/threonine kinase inhibitor activity GO:0030291 IEA     protein serine/threonine kinase inhibitor activity GO:0030291 ISO     heat shock protein binding GO:0031072 IBA     ubiquitin protein ligase binding GO:0031625 IEA     ubiquitin protein ligase binding GO:0031625 ISO     ribosome binding GO:0043022 IEA     ribosome binding GO:0043022 ISO     protein folding chaperone GO:0044183 IBA     protein folding chaperone GO:0044183 ISO     unfolded protein binding GO:0051082 IPI     misfolded protein binding GO:0051787 IDA     misfolded protein binding GO:0051787 IEA     misfolded protein binding GO:0051787 ISO     cohesin loader activity GO:0061775 IEA     chromatin extrusion motor activity GO:0140584 IEA     ATP-dependent protein folding chaperone GO:0140662 IEA     ATP-dependent H3-H4 histone complex chaperone activity GO:0140665 IEA     ATP-dependent H2AZ histone chaperone activity GO:0140849 IEA Biological Process     luteolysis GO:0001554 IEP     chromatin remodeling GO:0006338 IEA     protein folding GO:0006457 IEA     ER overload response GO:0006983 IEA     ER overload response GO:0006983 ISO     positive regulation of neuron projection development GO:0010976 IMP     cerebellum structural organization GO:0021589 IEA     cerebellum structural organization GO:0021589 ISO     cerebellar Purkinje cell layer development GO:0021680 IEA     cerebellar Purkinje cell layer development GO:0021680 ISO     substantia nigra development GO:0021762 ISO     neuron differentiation GO:0030182 IEP     positive regulation of cell migration GO:0030335 IEA     positive regulation of cell migration GO:0030335 ISO     positive regulation of cell migration GO:0030335 ISS     negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 IEA     negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 ISO     endoplasmic reticulum unfolded protein response GO:0030968 IBA     endoplasmic reticulum unfolded protein response GO:0030968 IEA     endoplasmic reticulum unfolded protein response GO:0030968 ISO     post-translational protein targeting to membrane, translocation GO:0031204 IEA     post-translational protein targeting to membrane, translocation GO:0031204 ISO     post-translational protein targeting to membrane, translocation GO:0031204 ISS     negative regulation of protein-containing complex assembly GO:0031333 ISS     positive regulation of protein ubiquitination GO:0031398 IEA     positive regulation of protein ubiquitination GO:0031398 ISO     response to endoplasmic reticulum stress GO:0034976 IDA     response to endoplasmic reticulum stress GO:0034976 IEP     maintenance of protein localization in endoplasmic reticulum GO:0035437 IEA     maintenance of protein localization in endoplasmic reticulum GO:0035437 ISO     maintenance of protein localization in endoplasmic reticulum GO:0035437 ISS     IRE1-mediated unfolded protein response GO:0036498 ISO     ERAD pathway GO:0036503 IBA     protein refolding GO:0042026 IBA     cellular response to glucose starvation GO:0042149 IEA     cellular response to glucose starvation GO:0042149 ISO     response to cocaine GO:0042220 IEP     negative regulation of apoptotic process GO:0043066 IEA     negative regulation of apoptotic process GO:0043066 ISO     chaperone cofactor-dependent protein refolding GO:0051085 IBA     neuron apoptotic process GO:0051402 IEP     proteolysis involved in protein catabolic process GO:0051603 IEA     proteolysis involved in protein catabolic process GO:0051603 ISO     cellular response to antibiotic GO:0071236 IEP     cellular response to calcium ion GO:0071277 IEP     cellular response to manganese ion GO:0071287 IEP     cellular response to cAMP GO:0071320 IEP     cellular response to interleukin-4 GO:0071353 IEA     cellular response to interleukin-4 GO:0071353 ISO     cellular response to xenobiotic stimulus GO:0071466 IEP     cellular response to gamma radiation GO:0071480 IEP     stress response to metal ion GO:0097501 IEP     chromatin looping GO:0140588 IEA     negative regulation of IRE1-mediated unfolded protein response GO:1903895 ISS     negative regulation of PERK-mediated unfolded protein response GO:1903898 IEA     negative regulation of PERK-mediated unfolded protein response GO:1903898 ISO     response to methamphetamine hydrochloride GO:1904313 IEP     cellular response to nerve growth factor stimulus GO:1990090 IEP Subcellular Localization     nucleus GO:0005634 IBA     nucleus GO:0005634 ISO     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 ISO     mitochondrion GO:0005739 IEA     mitochondrion GO:0005739 ISO     endoplasmic reticulum GO:0005783 IDA     endoplasmic reticulum GO:0005783 ISO     endoplasmic reticulum lumen GO:0005788 IBA     endoplasmic reticulum lumen GO:0005788 IEA     endoplasmic reticulum lumen GO:0005788 ISO     endoplasmic reticulum membrane GO:0005789 IEA     endoplasmic reticulum membrane GO:0005789 ISO     smooth endoplasmic reticulum GO:0005790 IDA     endoplasmic reticulum-Golgi intermediate compartment GO:0005793 IEA     endoplasmic reticulum-Golgi intermediate compartment GO:0005793 ISO     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     cytosol GO:0005829 ISS     plasma membrane GO:0005886 IEA     plasma membrane GO:0005886 ISO     COP9 signalosome GO:0008180 IEA     COP9 signalosome GO:0008180 ISO     cell surface GO:0009986 IEA     cell surface GO:0009986 ISO     membrane GO:0016020 IBA     membrane GO:0016020 IDA     midbody GO:0030496 IEA     midbody GO:0030496 ISO     protein-containing complex GO:0032991 ISO     endoplasmic reticulum chaperone complex GO:0034663 IBA     endoplasmic reticulum chaperone complex GO:0034663 IEA     endoplasmic reticulum chaperone complex GO:0034663 ISO     melanosome GO:0042470 IEA     neuronal cell body GO:0043025 IDA     dendritic shaft GO:0043198 IDA     intracellular membrane-bounded organelle GO:0043231 ISO