Gene description for FABP1
Gene name fatty acid binding protein 1, liver
Gene symbol FABP1
Other names/aliases FABPL
L-FABP
Species Homo sapiens
 Database cross references - FABP1
ExoCarta ExoCarta_2168
Vesiclepedia VP_2168
Entrez Gene 2168
HGNC 3555
MIM 134650
UniProt P07148  
 FABP1 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 34887515    
Urine 19056867    
 Gene ontology annotations for FABP1
Molecular Function
    protein binding GO:0005515 IPI
    fatty acid binding GO:0005504 IEA
    drug binding GO:0008144 IEA
    phospholipid binding GO:0005543 IEA
    long-chain fatty acid transporter activity GO:0005324 IEA
    bile acid binding GO:0032052 IEA
    antioxidant activity GO:0016209 IDA
    chromatin binding GO:0003682 IEA
Biological Process
    small molecule metabolic process GO:0044281 TAS
    positive regulation of hydrolase activity GO:0051345 IEA
    cellular response to hypoxia GO:0071456 IDA
    triglyceride catabolic process GO:0019433 TAS
    intestinal absorption GO:0050892 IEA
    long-chain fatty acid transport GO:0015909 IEA
    cellular lipid metabolic process GO:0044255 TAS
    activation of mitophagy in response to mitochondrial depolarization GO:0098779 IMP
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 IDA
    negative regulation of apoptotic process GO:0043066 IDA
    positive regulation of defense response to virus by host GO:0002230 IMP
    positive regulation of cell proliferation GO:0008284 IEA
    positive regulation of fatty acid beta-oxidation GO:0032000 IEA
    cellular response to hydrogen peroxide GO:0070301 IDA
Subcellular Localization
    apical cortex GO:0045179 IEA
    cytosol GO:0005829 TAS
    extracellular exosome GO:0070062 IDA
    peroxisomal matrix GO:0005782 ISS
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified FABP1 in exosomes
1
Experiment ID 1203
MISEV standards
✔
EM
EV Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ.
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
2
Experiment ID 63
MISEV standards
✘ EV Biophysical techniques
✔
AQP2
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for FABP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PPARG 5468
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
2 PPARA  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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