Gene description for Thbs2
Gene name thrombospondin 2
Gene symbol Thbs2
Other names/aliases TSP2
Species Mus musculus
 Database cross references - Thbs2
ExoCarta ExoCarta_21826
Entrez Gene 21826
UniProt Q03350  
 Thbs2 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Thbs2
Molecular Function
    heparin binding GO:0008201 IEA
    protein binding GO:0005515 IPI
    calcium ion binding GO:0005509 IEA
Biological Process
    negative regulation of angiogenesis GO:0016525 ISO
    cell adhesion GO:0007155 IEA
    positive regulation of synapse assembly GO:0051965 ISO
Subcellular Localization
    platelet alpha granule GO:0031091 ISO
    basement membrane GO:0005604 IDA
    extracellular region GO:0005576 IEA
    extracellular matrix GO:0031012 IEA
    proteinaceous extracellular matrix GO:0005578 IDA
 Experiment description of studies that identified Thbs2 in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Thbs2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Thbs2 is involved
Signaling by PDGF IEA Reactome

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