Gene description for Thbs2
Gene name thrombospondin 2
Gene symbol Thbs2
Other names/aliases TSP2
Thbs-2
Species Mus musculus
 Database cross references - Thbs2
ExoCarta ExoCarta_21826
Entrez Gene 21826
UniProt Q03350  
 Thbs2 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Thbs2
Molecular Function
    heparin binding GO:0008201 IEA
    protein binding GO:0005515 IPI
    calcium ion binding GO:0005509 IEA
Biological Process
    negative regulation of angiogenesis GO:0016525 ISO
    cell adhesion GO:0007155 IEA
    positive regulation of synapse assembly GO:0051965 ISO
Subcellular Localization
    platelet alpha granule GO:0031091 ISO
    basement membrane GO:0005604 IDA
    extracellular region GO:0005576 IEA
    extracellular matrix GO:0031012 IEA
    proteinaceous extracellular matrix GO:0005578 IDA
 Experiment description of studies that identified Thbs2 in exosomes
1
Experiment ID 210
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|FLOT1
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Thbs2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Thbs2 is involved
PathwayEvidenceSource
Signaling by PDGF IEA Reactome





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