Gene description for Tom1
Gene name target of myb1 homolog (chicken)
Gene symbol Tom1
Other names/aliases -
Species Mus musculus
 Database cross references - Tom1
ExoCarta ExoCarta_21968
Vesiclepedia VP_21968
Entrez Gene 21968
UniProt O88746  
 Tom1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Tom1
Molecular Function
    protein binding GO:0005515 IPI
    phosphatidylinositol-5-phosphate binding GO:0010314 ISO
    phosphatidylinositol-5-phosphate binding GO:0010314 ISS
    clathrin binding GO:0030276 IBA
    clathrin binding GO:0030276 ISO
    polyubiquitin modification-dependent protein binding GO:0031593 ISO
    polyubiquitin modification-dependent protein binding GO:0031593 ISS
    clathrin heavy chain binding GO:0032050 ISO
    clathrin heavy chain binding GO:0032050 ISS
    ubiquitin binding GO:0043130 ISO
    ubiquitin binding GO:0043130 ISS
    myosin VI binding GO:0070853 ISO
    myosin VI binding GO:0070853 ISS
Biological Process
    signal transduction GO:0007165 IBA
    protein transport GO:0015031 IEA
    endosomal transport GO:0016197 ISO
    endosomal transport GO:0016197 ISS
    substrate localization to autophagosome GO:0061753 ISO
    substrate localization to autophagosome GO:0061753 ISS
    autophagosome-lysosome fusion GO:0061909 ISO
    autophagosome-lysosome fusion GO:0061909 ISS
    positive regulation of autophagosome maturation GO:1901098 ISO
    positive regulation of autophagosome maturation GO:1901098 ISS
    regulation of endosome organization GO:1904978 ISO
    regulation of endosome organization GO:1904978 ISS
Subcellular Localization
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    endosome GO:0005768 IBA
    endosome GO:0005768 ISO
    endosome GO:0005768 ISS
    early endosome GO:0005769 ISO
    early endosome GO:0005769 ISS
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISS
    endosome membrane GO:0010008 ISO
    endosome membrane GO:0010008 ISS
    membrane GO:0016020 IBA
    membrane GO:0016020 ISO
    membrane GO:0016020 ISS
    early endosome membrane GO:0031901 IEA
 Experiment description of studies that identified Tom1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Tom1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Kctd13  
Affinity Capture-MS Mus musculus
2 Ubc  
Reconstituted Complex Mus musculus
Reconstituted Complex Mus musculus
3 Tbcd  
Co-fractionation Mus musculus
4 Eed  
Affinity Capture-MS Mus musculus
5 Tollip 54473
Co-fractionation Mus musculus
6 UBC 7316
Reconstituted Complex Homo sapiens
7 Tsg101 22088
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Tom1 is involved
PathwayEvidenceSource
Immune System IEA Reactome
Innate Immune System IEA Reactome
Neutrophil degranulation IEA Reactome





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