Gene description for Txn1
Gene name thioredoxin 1
Gene symbol Txn1
Other names/aliases ADF
AW550880
Trx1
Txn
Species Mus musculus
 Database cross references - Txn1
ExoCarta ExoCarta_22166
Vesiclepedia VP_22166
Entrez Gene 22166
UniProt P10639  
 Txn1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Txn1
Molecular Function
    protein disulfide oxidoreductase activity GO:0015035 IBA
    enzyme binding GO:0019899 ISO
    peptide disulfide oxidoreductase activity GO:0015037 IDA
    poly(A) RNA binding GO:0044822 ISO
    oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor GO:0016671 IBA
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of protein export from nucleus GO:0046826 IDA
    transcription, DNA-templated GO:0006351 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IGI
    cellular response to oxidative stress GO:0034599 IBA
    response to radiation GO:0009314 ISO
    negative regulation of hydrogen peroxide-induced cell death GO:1903206 ISO
    positive regulation of DNA binding GO:0043388 ISO
    cell redox homeostasis GO:0045454 IDA
    regulation of transcription, DNA-templated GO:0006355 IEA
    sulfate assimilation GO:0000103 IBA
    oxidation-reduction process GO:0055114 ISO
    transport GO:0006810 IEA
    glycerol ether metabolic process GO:0006662 IEA
    protein folding GO:0006457 IBA
    positive regulation of peptidyl-serine phosphorylation GO:0033138 ISO
    regulation of protein import into nucleus, translocation GO:0033158 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    neuronal cell body GO:0043025 ISO
    nucleus GO:0005634 ISO
    extracellular region GO:0005576 IEA
    extracellular exosome GO:0070062 ISO
    axon GO:0030424 ISO
    cytosol GO:0005829 ISO
    dendrite GO:0030425 ISO
    mitochondrion GO:0005739 IDA
 Experiment description of studies that identified Txn1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Txn1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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