Gene description for Wars
Gene name tryptophanyl-tRNA synthetase
Gene symbol Wars
Other names/aliases TrpRS
WRS
Species Mus musculus
 Database cross references - Wars
ExoCarta ExoCarta_22375
Entrez Gene 22375
UniProt P32921  
 Wars identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Wars
Molecular Function
    ligase activity GO:0016874 IEA
    ATP binding GO:0005524 IEA
    aminoacyl-tRNA ligase activity GO:0004812 IEA
    tryptophan-tRNA ligase activity GO:0004830 IEA
    nucleotide binding GO:0000166 IEA
Biological Process
    translation GO:0006412 IEA
    angiogenesis GO:0001525 IEA
    regulation of angiogenesis GO:0045765 ISO
    tRNA aminoacylation for protein translation GO:0006418 IEA
    tryptophanyl-tRNA aminoacylation GO:0006436 IEA
Subcellular Localization
    nucleus GO:0005634 ISO
    extracellular exosome GO:0070062 ISO
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Wars in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Wars
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Wars is involved
No pathways found





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