Gene description for Sf1
Gene name splicing factor 1
Gene symbol Sf1
Other names/aliases BBP
MZFM
WBP4
Zfp162
Species Mus musculus
 Database cross references - Sf1
ExoCarta ExoCarta_22668
Entrez Gene 22668
 Sf1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Sf1
Molecular Function
    zinc ion binding GO:0008270 IEA
    RNA binding GO:0003723 IEA
    metal ion binding GO:0046872 IEA
    nucleic acid binding GO:0003676 IEA
Biological Process
    RNA splicing GO:0008380 IEA
    transcription, DNA-templated GO:0006351 IEA
    male sex determination GO:0030238 IGI
    Leydig cell differentiation GO:0033327 IGI
    regulation of steroid biosynthetic process GO:0050810 IGI
    negative regulation of smooth muscle cell proliferation GO:0048662 ISO
    mRNA processing GO:0006397 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
Subcellular Localization
    nucleus GO:0005634 ISS
    spliceosomal complex GO:0005681 IEA
    cytoplasm GO:0005737 ISS
 Experiment description of studies that identified Sf1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Sf1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Sf1 is involved
No pathways found





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