Gene description for Prkaca
Gene name protein kinase, cAMP-dependent, catalytic, alpha
Gene symbol Prkaca
Other names/aliases Cs-PKA
PKCA1
Species Rattus norvegicus
 Database cross references - Prkaca
ExoCarta ExoCarta_25636
Entrez Gene 25636
 Prkaca identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Prkaca
Molecular Function
    protein kinase activity GO:0004672 ISO
    ubiquitin protein ligase binding GO:0031625 ISO
    cAMP-dependent protein kinase activity GO:0004691 ISO
    Rab GTPase binding GO:0017137 IPI
    protein kinase A regulatory subunit binding GO:0034237 ISO
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 ISO
    protein complex binding GO:0032403 IPI
    ATP binding GO:0005524 IEA
    protein serine/threonine kinase activity GO:0004674 ISO
    protein serine/threonine/tyrosine kinase activity GO:0004712 ISO
Biological Process
    regulation of bicellular tight junction assembly GO:2000810 ISO
    positive regulation of cell cycle arrest GO:0071158 ISO
    regulation of proteasomal protein catabolic process GO:0061136 ISO
    sperm capacitation GO:0048240 ISO
    neural tube closure GO:0001843 ISO
    regulation of cellular respiration GO:0043457 IDA
    positive regulation of protein export from nucleus GO:0046827 ISO
    mesoderm formation GO:0001707 ISO
    regulation of synaptic transmission, glutamatergic GO:0051966 IDA
    regulation of synaptic transmission GO:0050804 ISO
    negative regulation of meiotic cell cycle GO:0051447 IDA
    regulation of osteoblast differentiation GO:0045667 ISO
    positive regulation of cell proliferation GO:0008284 IMP
    protein phosphorylation GO:0006468 ISO
    cellular response to parathyroid hormone stimulus GO:0071374 ISO
    peptidyl-serine phosphorylation GO:0018105 ISO
    peptidyl-threonine phosphorylation GO:0018107 ISO
    negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning GO:1901621 ISO
    regulation of protein processing GO:0070613 ISO
    protein autophosphorylation GO:0046777 ISO
    cellular response to glucose stimulus GO:0071333 ISO
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    AMP-activated protein kinase complex GO:0031588 ISO
    cAMP-dependent protein kinase complex GO:0005952 IDA
    nucleus GO:0005634 ISO
    motile cilium GO:0031514 IEA
    membrane GO:0016020 ISO
    protein complex GO:0043234 IDA
    cytoplasm GO:0005737 ISO
    neuron projection GO:0043005 IDA
    Golgi apparatus GO:0005794 IDA
    mitochondrion GO:0005739 ISO
    centrosome GO:0005813 ISO
    sperm midpiece GO:0097225 ISS
    cytosol GO:0005829 TAS
    ciliary base GO:0097546 ISO
    perinuclear region of cytoplasm GO:0048471 IDA
    plasma membrane GO:0005886 ISO
    neuromuscular junction GO:0031594 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Prkaca in exosomes
1
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Prkaca
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Prkaca is involved
No pathways found





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