Gene description for TIAM2
Gene name T-cell lymphoma invasion and metastasis 2
Gene symbol TIAM2
Other names/aliases STEF
TIAM-2
Species Homo sapiens
 Database cross references - TIAM2
ExoCarta ExoCarta_26230
Entrez Gene 26230
HGNC 11806
MIM 604709
UniProt Q8IVF5  
 TIAM2 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for TIAM2
Molecular Function
    GTPase activator activity GO:0005096 IEA
    guanyl-nucleotide exchange factor activity GO:0005085 TAS
    Rho guanyl-nucleotide exchange factor activity GO:0005089 IEA
    receptor signaling protein activity GO:0005057 IEA
Biological Process
    cellular lipid metabolic process GO:0044255 TAS
    positive regulation of apoptotic process GO:0043065 TAS
    regulation of small GTPase mediated signal transduction GO:0051056 TAS
    small molecule metabolic process GO:0044281 TAS
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    apoptotic signaling pathway GO:0097190 TAS
    positive regulation of GTPase activity GO:0043547 IEA
    small GTPase mediated signal transduction GO:0007264 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    extracellular exosome GO:0070062 IDA
    lamellipodium GO:0030027 IEA
    membrane GO:0016020 IEA
    filopodium GO:0030175 IEA
    growth cone GO:0030426 IEA
 Experiment description of studies that identified TIAM2 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for TIAM2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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