Gene description for Plod3
Gene name procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
Gene symbol Plod3
Other names/aliases AI414586
Species Mus musculus
 Database cross references - Plod3
ExoCarta ExoCarta_26433
Entrez Gene 26433
UniProt Q9R0E1  
 Plod3 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Plod3
Molecular Function
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 IEA
    procollagen-lysine 5-dioxygenase activity GO:0008475 IDA
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors GO:0016706 IEA
    L-ascorbic acid binding GO:0031418 IEA
    dioxygenase activity GO:0051213 IEA
    procollagen glucosyltransferase activity GO:0033823 IDA
    oxidoreductase activity GO:0016491 IEA
    metal ion binding GO:0046872 IEA
    iron ion binding GO:0005506 IEA
Biological Process
    basement membrane assembly GO:0070831 IMP
    neural tube development GO:0021915 IMP
    in utero embryonic development GO:0001701 IMP
    oxidation-reduction process GO:0055114 IDA
    collagen fibril organization GO:0030199 IMP
    protein localization GO:0008104 IMP
    epidermis morphogenesis GO:0048730 IMP
    endothelial cell morphogenesis GO:0001886 IMP
    vasodilation GO:0042311 IMP
    lung morphogenesis GO:0060425 IMP
Subcellular Localization
    endoplasmic reticulum GO:0005783 IEA
    extracellular exosome GO:0070062 ISO
    membrane GO:0016020 IEA
 Experiment description of studies that identified Plod3 in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Plod3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Plod3 is involved
Collagen biosynthesis and modifying enzymes IEA Reactome

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