Gene description for Stub1
Gene name	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
Gene symbol	Stub1
Other names/aliases	Chip
Species	Rattus norvegicus
Database cross references - Stub1
ExoCarta	ExoCarta_287155
Vesiclepedia	VP_287155
Entrez Gene	287155
Stub1 identified in exosomes derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Stub1

Molecular Function     G protein-coupled receptor binding GO:0001664 ISO     ubiquitin-protein transferase activity GO:0004842 IEA     ubiquitin-protein transferase activity GO:0004842 ISO     protein binding GO:0005515 IPI     enzyme binding GO:0019899 ISO     kinase binding GO:0019900 ISO     Hsp70 protein binding GO:0030544 ISO     TPR domain binding GO:0030911 ISO     heat shock protein binding GO:0031072 ISO     ubiquitin protein ligase binding GO:0031625 ISO     ubiquitin-ubiquitin ligase activity GO:0034450 ISO     protein homodimerization activity GO:0042803 ISO     SMAD binding GO:0046332 ISO     protein-folding chaperone binding GO:0051087 ISO     misfolded protein binding GO:0051787 ISO     Hsp90 protein binding GO:0051879 ISO     ubiquitin protein ligase activity GO:0061630 IDA     ubiquitin protein ligase activity GO:0061630 IMP     ubiquitin protein ligase activity GO:0061630 ISO     R-SMAD binding GO:0070412 ISO Biological Process     MAPK cascade GO:0000165 IMP     protein polyubiquitination GO:0000209 ISO     protein polyubiquitination GO:0000209 ISO     DNA repair GO:0006281 IEA     ubiquitin-dependent protein catabolic process GO:0006511 ISO     protein monoubiquitination GO:0006513 ISO     protein quality control for misfolded or incompletely synthesized proteins GO:0006515 ISO     negative regulation of cardiac muscle hypertrophy GO:0010614 IMP     protein ubiquitination GO:0016567 IDA     protein ubiquitination GO:0016567 IEA     protein ubiquitination GO:0016567 IMP     protein ubiquitination GO:0016567 ISO     negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 ISO     endoplasmic reticulum unfolded protein response GO:0030968 ISO     positive regulation of protein ubiquitination GO:0031398 ISO     regulation of protein stability GO:0031647 ISO     regulation of glucocorticoid metabolic process GO:0031943 ISO     positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 ISO     negative regulation of smooth muscle cell apoptotic process GO:0034392 IMP     negative regulation of smooth muscle cell apoptotic process GO:0034392 ISO     negative regulation of smooth muscle cell apoptotic process GO:0034392 ISS     positive regulation of smooth muscle cell apoptotic process GO:0034393 IMP     negative regulation of peroxisome proliferator activated receptor signaling pathway GO:0035359 ISS     ERAD pathway GO:0036503 ISO     negative regulation of apoptotic process GO:0043066 IMP     proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISO     proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISS     positive regulation of proteolysis GO:0045862 ISO     protein stabilization GO:0050821 ISO     positive regulation of ubiquitin-protein transferase activity GO:0051443 ISO     protein autoubiquitination GO:0051865 ISO     protein K63-linked ubiquitination GO:0070534 ISO     cellular response to misfolded protein GO:0071218 ISO     positive regulation of chaperone-mediated protein complex assembly GO:0090035 ISO     positive regulation of mitophagy GO:1901526 IMP     positive regulation of ERAD pathway GO:1904294 ISO     negative regulation of vascular associated smooth muscle contraction GO:1904694 IMP Subcellular Localization     ubiquitin ligase complex GO:0000151 ISO     nucleus GO:0005634 IDA     nucleus GO:0005634 ISO     nucleoplasm GO:0005654 IEA     nucleoplasm GO:0005654 ISO     cytoplasm GO:0005737 IDA     cytoplasm GO:0005737 ISO     mitochondrion GO:0005739 IDA     endoplasmic reticulum GO:0005783 ISO     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     Z disc GO:0030018 ISO     nuclear inclusion body GO:0042405 ISO     protein folding chaperone complex GO:0101031 ISO