Gene description for HPD
Gene name 4-hydroxyphenylpyruvate dioxygenase
Gene symbol HPD
Other names/aliases 4-HPPD
4HPPD
GLOD3
HPPDASE
PPD
Species Homo sapiens
 Database cross references - HPD
ExoCarta ExoCarta_3242
Entrez Gene 3242
HGNC 5147
MIM 609695
UniProt P32754  
 HPD identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for HPD
Molecular Function
    4-hydroxyphenylpyruvate dioxygenase activity GO:0003868 ISS
    metal ion binding GO:0046872 IEA
Biological Process
    small molecule metabolic process GO:0044281 TAS
    L-phenylalanine catabolic process GO:0006559 TAS
    oxidation-reduction process GO:0055114 IEA
    tyrosine catabolic process GO:0006572 ISS
    cellular nitrogen compound metabolic process GO:0034641 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified HPD in exosomes
1
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for HPD
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which HPD is involved
PathwayEvidenceSource
Phenylalanine and tyrosine catabolism TAS Reactome





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