Gene description for ITGAX
Gene name integrin, alpha X (complement component 3 receptor 4 subunit)
Gene symbol ITGAX
Other names/aliases CD11C
Species Homo sapiens
 Database cross references - ITGAX
ExoCarta ExoCarta_3687
Entrez Gene 3687
HGNC 6152
MIM 151510
UniProt P20702  
 ITGAX identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for ITGAX
Molecular Function
    protein binding GO:0005515 IPI
    receptor activity GO:0004872 TAS
    metal ion binding GO:0046872 IEA
Biological Process
    positive regulation of protein targeting to mitochondrion GO:1903955 IMP
    heterotypic cell-cell adhesion GO:0034113 IMP
    extracellular matrix organization GO:0030198 TAS
    blood coagulation GO:0007596 TAS
    organ morphogenesis GO:0009887 TAS
    leukocyte migration GO:0050900 TAS
    cell adhesion GO:0007155 TAS
    integrin-mediated signaling pathway GO:0007229 IEA
Subcellular Localization
    integrin complex GO:0008305 IEA
    cell surface GO:0009986 IDA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 IDA
 Experiment description of studies that identified ITGAX in exosomes
Experiment ID 217
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ITGAX
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 JAM3 83700
Invivo Homo sapiens
2 ITGB2 3689
Invivo Homo sapiens
3 C3 718
Reconstituted Complex Homo sapiens
4 FCER2 2208
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml

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