Gene description for zip
Gene name zipper
Gene symbol zip
Other names/aliases CG15792
DROMHC
Dm nmII
DmelCG15792
DmnmII
Dronm-MII
E(br)
MHC
Mhc-c
Mhc-c[1]
Myo
Myo II
Myo-II
Myo-II HC
Myo2
MyoII
NMM
NMMII
ZIP
Zip
anon-WO0140519.37
l(2)02957
l(2)17F1
myo II
myoII
nmMHC
nmy-2
zip/MyoII
zpr
Species Drosophila melanogaster
 Database cross references - zip
ExoCarta ExoCarta_38001
Vesiclepedia VP_38001
Entrez Gene 38001
UniProt Q99323  
 zip identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for zip
Molecular Function
    protein binding GO:0005515 IPI
    myosin light chain binding GO:0032027 IPI
Biological Process
    mitotic cytokinesis GO:0000281 IMP
    muscle contraction GO:0006936 IMP
    border follicle cell migration GO:0007298 IMP
    dorsal closure GO:0007391 IGI
    dorsal closure GO:0007391 IMP
    dorsal closure, spreading of leading edge cells GO:0007395 IMP
    salivary gland morphogenesis GO:0007435 IMP
    Malpighian tubule morphogenesis GO:0007443 IMP
    eye-antennal disc morphogenesis GO:0007455 IMP
    anterior midgut development GO:0007496 IMP
    sensory perception of sound GO:0007605 IMP
    head involution GO:0008258 IMP
    muscle attachment GO:0016203 IGI
    myofibril assembly GO:0030239 IMP
    myosin II filament assembly GO:0031036 IDA
    maintenance of protein location in cell GO:0032507 IMP
    cuticle pattern formation GO:0035017 IMP
    regulation of tube length, open tracheal system GO:0035159 IMP
    spiracle morphogenesis, open tracheal system GO:0035277 IDA
    imaginal disc-derived wing hair organization GO:0035317 IGI
    wound healing GO:0042060 IMP
    sarcomere organization GO:0045214 IMP
    dorsal closure, leading edge cell differentiation GO:0046663 IMP
    dorsal closure, amnioserosa morphology change GO:0046664 IMP
    compartment boundary maintenance GO:0060289 IMP
    morphogenesis of an epithelial fold GO:0060571 IMP
    cytoskeleton-dependent cytokinesis GO:0061640 IMP
    left/right axis specification GO:0070986 IMP
    cellular response to mechanical stimulus GO:0071260 IDA
    regulation of establishment of planar polarity GO:0090175 IMP
    regulation of myoblast fusion GO:1901739 IGI
    positive regulation of border follicle cell migration GO:1903688 IMP
Subcellular Localization
    actomyosin contractile ring GO:0005826 IDA
    cytosol GO:0005829 HDA
    cell cortex GO:0005938 IDA
    cell cortex GO:0005938 IMP
    myosin II complex GO:0016460 IDA
    myosin II complex GO:0016460 IPI
    Z disc GO:0030018 IDA
    cell leading edge GO:0031252 IDA
    cleavage furrow GO:0032154 IDA
    cell-cell contact zone GO:0044291 IDA
    apical cortex GO:0045179 IDA
    basal cortex GO:0045180 IDA
    contractile ring GO:0070938 HDA
    apicomedial cortex GO:0106037 IDA
 Experiment description of studies that identified zip in exosomes
1
Experiment ID 202
MISEV standards
IEM
Biophysical techniques
TSG10|RAB35|FLOT2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for zip
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 cry  
Proximity Label-MS Drosophila melanogaster
2 awd  
Affinity Capture-MS Drosophila melanogaster
3 eap  
Affinity Capture-MS Drosophila melanogaster
4 CG9689  
Affinity Capture-MS Drosophila melanogaster
5 CG33107  
Affinity Capture-MS Drosophila melanogaster
6 Df31  
Affinity Capture-MS Drosophila melanogaster
7 CG1885  
Affinity Capture-MS Drosophila melanogaster
8 CG1792  
Two-hybrid Drosophila melanogaster
9 CG32445  
Affinity Capture-MS Drosophila melanogaster
10 Mlc-c 31474
Affinity Capture-MS Drosophila melanogaster
11 Capa  
Affinity Capture-MS Drosophila melanogaster
12 Pglym87  
Affinity Capture-MS Drosophila melanogaster
13 CG8149  
Affinity Capture-MS Drosophila melanogaster
14 7B2  
Affinity Capture-MS Drosophila melanogaster
15 CG11459  
Affinity Capture-MS Drosophila melanogaster
16 Dat  
Affinity Capture-MS Drosophila melanogaster
17 scpr-C  
Affinity Capture-MS Drosophila melanogaster
18 Sry-alpha  
Two-hybrid Drosophila melanogaster
19 Tm1 41852
Affinity Capture-MS Drosophila melanogaster
20 Fibp  
Affinity Capture-MS Drosophila melanogaster
21 CG5590  
Affinity Capture-MS Drosophila melanogaster
22 Rab6  
Two-hybrid Drosophila melanogaster
23 CG7366  
Affinity Capture-MS Drosophila melanogaster
24 regucalcin  
Affinity Capture-MS Drosophila melanogaster
25 retinin  
Affinity Capture-MS Drosophila melanogaster
26 Eogt  
Affinity Capture-MS Drosophila melanogaster
27 Swip-1 35158
Affinity Capture-MS Drosophila melanogaster
28 calypso  
Affinity Capture-MS Drosophila melanogaster
29 CG4662  
Affinity Capture-MS Drosophila melanogaster
30 Rad51D  
Two-hybrid Drosophila melanogaster
31 Rae1  
Affinity Capture-MS Drosophila melanogaster
32 CG6163  
Two-hybrid Drosophila melanogaster
33 CTPsyn  
Proximity Label-MS Drosophila melanogaster
34 CG10194  
Affinity Capture-MS Drosophila melanogaster
35 CG1809  
Affinity Capture-MS Drosophila melanogaster
36 CG31546  
Affinity Capture-MS Drosophila melanogaster
37 CG9377  
Affinity Capture-MS Drosophila melanogaster
38 CG6347  
Affinity Capture-MS Drosophila melanogaster
View the network image/svg+xml



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