Gene description for Tm1
Gene name Tropomyosin 1
Gene symbol Tm1
Other names/aliases 1305/10
2299
BcDNA:GH09289
BcDNA:LD37158
BcDNA:SD21996
CG4898
Dm Tm1
Dm TmH33
Dm TmH34
DmTm1
DmelCG4898
PmI
TM
TM1
TMII
Tm
TmH
TmH-33
TmH-34
TmH33
TmH34
TmII
Tmr33
Tmr34
TnH
TnH-33
TnH-34
cTM
cTm
cTmII
chr3R:11122272..11122408
l(3)02299
l(3)S130510
l(3)s2958
mTmII
region 3
tm1
tmII
tropomyosin
Species Drosophila melanogaster
 Database cross references - Tm1
ExoCarta ExoCarta_41852
Vesiclepedia VP_41852
Entrez Gene 41852
UniProt P06754   P49455  
 Tm1 identified in sEVs derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Tm1
Molecular Function
    actin binding GO:0003779 TAS
    kinesin binding GO:0019894 IPI
    protein kinase binding GO:0019901 IPI
    actin filament binding GO:0051015 IDA
Biological Process
    muscle contraction GO:0006936 NAS
    pole plasm assembly GO:0007315 NAS
    regulation of lamellipodium assembly GO:0010591 IMP
    stress fiber assembly GO:0043149 IMP
    pole plasm oskar mRNA localization GO:0045451 IMP
    pole plasm oskar mRNA localization GO:0045451 TAS
    oogenesis GO:0048477 TAS
    dendrite morphogenesis GO:0048813 IMP
    dendrite morphogenesis GO:0048813 TAS
    response to hyperoxia GO:0055093 IMP
Subcellular Localization
    stress fiber GO:0001725 IMP
    cytosol GO:0005829 HDA
    sarcomere GO:0030017 IDA
    cortical actin cytoskeleton GO:0030864 IMP
    P granule GO:0043186 IDA
    investment cone GO:0070865 IDA
 Experiment description of studies that identified Tm1 in sEVs
1
Experiment ID 202
MISEV standards
IEM
Biophysical techniques
TSG10|RAB35|FLOT2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Tm1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Pig1  
Two-hybrid Drosophila melanogaster
2 Mlc-c 31474
Affinity Capture-MS Drosophila melanogaster
3 CG17329  
Two-hybrid Drosophila melanogaster
4 CG14454  
Two-hybrid Drosophila melanogaster
5 CG4213  
Two-hybrid Drosophila melanogaster
6 Rpt6  
Two-hybrid Drosophila melanogaster
7 dgrn  
Two-hybrid Drosophila melanogaster
8 SIP3  
Two-hybrid Drosophila melanogaster
9 CG6654  
Two-hybrid Drosophila melanogaster
10 CG11459  
Affinity Capture-MS Drosophila melanogaster
11 Dat  
Affinity Capture-MS Drosophila melanogaster
12 CG17599  
Two-hybrid Drosophila melanogaster
13 Tm1 41852
Two-hybrid Drosophila melanogaster
Two-hybrid Drosophila melanogaster
14 Jra  
Two-hybrid Drosophila melanogaster
15 p53  
Affinity Capture-Western Drosophila melanogaster
16 CG5516  
Two-hybrid Drosophila melanogaster
17 CG13477  
Two-hybrid Drosophila melanogaster
18 CG13476  
Two-hybrid Drosophila melanogaster
19 CG5376  
Two-hybrid Drosophila melanogaster
Two-hybrid Drosophila melanogaster
20 CG12546  
Two-hybrid Drosophila melanogaster
21 CG6769  
Two-hybrid Drosophila melanogaster
22 Swip-1 35158
Affinity Capture-MS Drosophila melanogaster
23 Fibp  
Affinity Capture-MS Drosophila melanogaster
24 CG40228  
Two-hybrid Drosophila melanogaster
25 CG9040  
Two-hybrid Drosophila melanogaster
26 Pnn  
Two-hybrid Drosophila melanogaster
27 HP5  
Two-hybrid Drosophila melanogaster
28 CG7164  
Two-hybrid Drosophila melanogaster
29 CG31368  
Two-hybrid Drosophila melanogaster
30 CG12491  
Two-hybrid Drosophila melanogaster
31 Exo70  
Two-hybrid Drosophila melanogaster
32 zip 38001
Affinity Capture-MS Drosophila melanogaster
33 RpS19b  
Two-hybrid Drosophila melanogaster
34 Dip1  
Two-hybrid Drosophila melanogaster
35 CG10681  
Two-hybrid Drosophila melanogaster
36 CG30349  
Two-hybrid Drosophila melanogaster
37 Blos2  
Two-hybrid Drosophila melanogaster
View the network image/svg+xml
 Pathways in which Tm1 is involved
No pathways found





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