Gene description for Zbtb2
Gene name zinc finger and BTB domain containing 2
Gene symbol Zbtb2
Other names/aliases Gm1103
Species Mus musculus
 Database cross references - Zbtb2
ExoCarta ExoCarta_381990
Vesiclepedia VP_381990
Entrez Gene 381990
 Zbtb2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Zbtb2
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 ISO
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IBA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 ISO
    identical protein binding GO:0042802 ISO
    sequence-specific double-stranded DNA binding GO:1990837 ISO
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IBA
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    regulation of cytokine production GO:0001817 IBA
    regulation of immune system process GO:0002682 IBA
Subcellular Localization
    nucleoplasm GO:0005654 IBA
 Experiment description of studies that identified Zbtb2 in exosomes
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Zbtb2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ENO1 2023
Affinity Capture-MS Homo sapiens
2 EPPK1 83481
Affinity Capture-MS Homo sapiens
3 KNOP1 400506
Affinity Capture-MS Homo sapiens
4 ZNF639  
Affinity Capture-MS Homo sapiens
5 Sall4  
Affinity Capture-MS Mus musculus
6 Pou5f1  
Affinity Capture-MS Mus musculus
7 TARBP1 6894
Affinity Capture-MS Homo sapiens
8 SORBS1 10580
Affinity Capture-MS Homo sapiens
9 Nanog  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Zbtb2 is involved
No pathways found





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