Gene description for MGST2
Gene name microsomal glutathione S-transferase 2
Gene symbol MGST2
Other names/aliases GST2
MGST-II
Species Homo sapiens
 Database cross references - MGST2
ExoCarta ExoCarta_4258
Entrez Gene 4258
HGNC 7063
MIM 601733
UniProt Q99735  
 MGST2 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for MGST2
Molecular Function
    enzyme activator activity GO:0008047 IEA
    glutathione transferase activity GO:0004364 IDA
    leukotriene-C4 synthase activity GO:0004464 IDA
    glutathione peroxidase activity GO:0004602 IBA
Biological Process
    glutathione derivative biosynthetic process GO:1901687 TAS
    small molecule metabolic process GO:0044281 TAS
    response to organonitrogen compound GO:0010243 IEA
    leukotriene biosynthetic process GO:0019370 IDA
    positive regulation of catalytic activity GO:0043085 IEA
    xenobiotic metabolic process GO:0006805 TAS
    response to lipopolysaccharide GO:0032496 IEA
    glutathione biosynthetic process GO:0006750 IDA
    oxidation-reduction process GO:0055114 IEA
Subcellular Localization
    intracellular membrane-bounded organelle GO:0043231 IDA
    plasma membrane GO:0005886 IDA
    integral component of membrane GO:0016021 IEA
    nuclear envelope GO:0005635 IBA
    endoplasmic reticulum membrane GO:0005789 TAS
 Experiment description of studies that identified MGST2 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MGST2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MGST2 is involved
PathwayEvidenceSource
Aflatoxin activation and detoxification TAS Reactome
Glutathione conjugation TAS Reactome





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