Gene description for Vps2
Gene name Vacuolar protein sorting 2
Gene symbol Vps2
Other names/aliases CG14542
Did4
DmVPS2
DmelCG14542
NEST:bs02f06
dvps2
vps2
Species Drosophila melanogaster
 Database cross references - Vps2
ExoCarta ExoCarta_43164
Vesiclepedia VP_43164
Entrez Gene 43164
 Vps2 identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Vps2
Biological Process
    endosomal transport GO:0016197 IMP
    endosome transport via multivesicular body sorting pathway GO:0032509 IMP
    ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 IMP
    negative regulation of viral entry into host cell GO:0046597 HMP
Subcellular Localization
    ESCRT III complex GO:0000815 ISS
    early endosome GO:0005769 IDA
    multivesicular body GO:0005771 IDA
 Experiment description of studies that identified Vps2 in exosomes
1
Experiment ID 202
MISEV standards
IEM
Biophysical techniques
TSG10|RAB35|FLOT2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Vps2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Vps24 40542
Affinity Capture-MS Drosophila melanogaster
Two-hybrid Drosophila melanogaster
2 mib2 35170
Affinity Capture-MS Drosophila melanogaster
3 CG2224  
Two-hybrid Drosophila melanogaster
4 Flo1  
Affinity Capture-MS Drosophila melanogaster
5 CG6259 39964
Affinity Capture-MS Drosophila melanogaster
6 CHMP2B 38599
Affinity Capture-MS Drosophila melanogaster
7 shrb  
Affinity Capture-MS Drosophila melanogaster
8 Chmp1  
Affinity Capture-MS Drosophila melanogaster
9 CG5107  
Two-hybrid Drosophila melanogaster
10 dl  
Two-hybrid Drosophila melanogaster
11 Vps4  
Affinity Capture-MS Drosophila melanogaster
12 CG10103 38750
Affinity Capture-MS Drosophila melanogaster
View the network image/svg+xml
 Pathways in which Vps2 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here