Gene description for Vps2
Gene name Vacuolar protein sorting 2
Gene symbol Vps2
Other names/aliases CG14542
Did4
DmVPS2
DmelCG14542
NEST:bs02f06
dvps2
vps2
Species Drosophila melanogaster
 Database cross references - Vps2
ExoCarta ExoCarta_43164
Entrez Gene 43164
 Vps2 identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Vps2
Molecular Function
    molecular_function GO:0003674 ND
Biological Process
    vacuolar transport GO:0007034 IEA
    endosome transport via multivesicular body sorting pathway GO:0032509 IMP
    negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 IMP
    endosomal transport GO:0016197 IMP
    negative regulation of Notch signaling pathway GO:0045746 IMP
    regulation of Notch signaling pathway GO:0008593 IMP
    ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 IMP
Subcellular Localization
    early endosome GO:0005769 IDA
    ESCRT III complex GO:0000815 ISS
    multivesicular body GO:0005771 IDA
 Experiment description of studies that identified Vps2 in exosomes
1
Experiment ID 202
ISEV standards
IEM
EV Biophysical techniques
TSG10|RAB35
EV Cytosolic markers
FLOT2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Vps2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Vps2 is involved
No pathways found





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