Gene description for CHMP2B
Gene name Charged multivesicular body protein 2b
Gene symbol CHMP2B
Other names/aliases CG4618
DmelCG4618
cg4618
Species Drosophila melanogaster
 Database cross references - CHMP2B
ExoCarta ExoCarta_38599
Vesiclepedia VP_38599
Entrez Gene 38599
 CHMP2B identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for CHMP2B
Subcellular Localization
    ESCRT III complex GO:0000815 ISS
 Experiment description of studies that identified CHMP2B in exosomes
1
Experiment ID 202
MISEV standards
IEM
Biophysical techniques
TSG10|RAB35|FLOT2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CHMP2B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Vps24 40542
Affinity Capture-MS Drosophila melanogaster
2 Vps2 43164
Affinity Capture-MS Drosophila melanogaster
3 mib2 35170
Affinity Capture-MS Drosophila melanogaster
4 CheB42b  
Two-hybrid Drosophila melanogaster
5 CG6259 39964
Affinity Capture-MS Drosophila melanogaster
6 Vdup1  
Affinity Capture-MS Drosophila melanogaster
7 Tom20  
Proximity Label-MS Drosophila melanogaster
8 shrb  
Affinity Capture-MS Drosophila melanogaster
9 Chmp1  
Affinity Capture-MS Drosophila melanogaster
10 Vps4  
Affinity Capture-MS Drosophila melanogaster
11 CG10103 38750
Affinity Capture-MS Drosophila melanogaster
12 zuc  
Proximity Label-MS Drosophila melanogaster
13 Flo2 32425
Affinity Capture-MS Drosophila melanogaster
View the network image/svg+xml
 Pathways in which CHMP2B is involved
No pathways found





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