Gene description for CG6259
Gene name CG6259 gene product from transcript CG6259-RB
Gene symbol CG6259
Other names/aliases Chmp5
DmelCG6259
VPS60
anon-74EFb
bs36h07.y1
Species Drosophila melanogaster
 Database cross references - CG6259
ExoCarta ExoCarta_39964
Entrez Gene 39964
UniProt Q9VVI9  
 CG6259 identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for CG6259
Molecular Function
    molecular_function GO:0003674 ND
Biological Process
    vacuolar transport GO:0007034 IEA
    germarium-derived egg chamber formation GO:0007293 IMP
    endosome transport via multivesicular body sorting pathway GO:0032509 ISS
    positive regulation of endocytosis GO:0045807 IMP
    negative regulation of JAK-STAT cascade GO:0046426 IMP
    negative regulation of epithelial cell proliferation GO:0050680 IMP
    ovarian follicle cell stalk formation GO:0030713 IMP
    epithelium development GO:0060429 IMP
Subcellular Localization
    ESCRT III complex GO:0000815 NAS
 Experiment description of studies that identified CG6259 in exosomes
1
Experiment ID 202
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG10|RAB35
EV Cytosolic markers
✔
FLOT2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CG6259
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CG6259 is involved
PathwayEvidenceSource
Endosomal Sorting Complex Required For Transport (ESCRT) IEA Reactome





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